274 jobs found in Tarrytown

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases. Summary: As part of the Law Department, this attorney will serve as counsel for the company in connection with licensing, business development and strategic transactions. This attorney will be responsible for drafting, reviewing and negotiating agreements and providing advice to senior management regarding proposed transactions, as well as compliance with existing contractual obligations, company policy and the law. The successful candidate will have demonstrated experience in structuring complex transactions, drafting agreements and transactional documents, advising on intellectual property matters and licensing arrangements, general corporate matters, risk management and regulatory matters relevant to the biotechnology and pharmaceuticals industries. The ideal candidate will have proven experience in effectively and collaboratively counseling clients. Responsibilities: • Works closely with senior management and the business development team on major corporate initiatives, including collaborations, partnerships, licensing agreements, etc. • Supports critical collaborations with the alliance management team and serves as an advisor as required. • Negotiates and drafts highly sophisticated licensing, collaboration and other agreements, often where no precedents exist. • Works closely with the intellectual property department to ensure proper protection of intellectual property assets. • Advises on relevant regulatory and legal matters impacting existing or proposed arrangements, including privacy, antitrust, securities and corporate law and regulations. • Oversees and coordinates relevant legal matters handled by outside counsel. Essential Skills and Abilities: • Draft, negotiate and bring to execution critical agreements for the company. • History of self-motivation, working independently on projects, meeting aggressive deadlines, and juggling multiple matters. • History of proven leadership and the ability to manage cross-function teams that include employees at different levels of the company. Requirements: • BA/BS and JD with excellent law school credentials. • Must have demonstrated expertise with negotiating and drafting complex agreements in the biotech, pharmaceutical and/or life sciences area (biotech preferred). • In-house experience preferred. • Minimum of 8+ years of relevant experience. Deal sheet preferred with CV. • Licensed to practice law in New York or be eligible for licensure as a registered in-house counsel. #LI-PD1 #INDG&A This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business. To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases. We are looking for a Director of Process Data Enablement and Analytics. This person will be responsible for establishing and leading a new function within Preclinical Manufacturing and Process Development (PMPD) that will be accountable for the management and oversight of PMPD operational data and data systems. This includes the development of data life cycle requirements, the assurance of data quality, availability, and security, the establishments of analytical tools, and requisite business and technology standards and practices. Key deliverables will include database, software, hardware, and procedural solutions aligned to the strategic roadmap for PMPD Operation and Information Technologies (OT and IT) aimed at the conversion of data into knowledge. This position will be providing leadership and mentoring for existing data managers within a distributed model and therefore closely partner with PMPD Data Managers, PMPD Senior Management, and Regeneron's IT organization to consistently improve PMPD's process data capabilities to facilitate process optimization and understanding. Responsibilities include: • Responsible for the formation and oversight of emerging PMPD data management group, which will be responsible for the design, maintenance and continued development of PMPD data systems and infrastructure used to acquire, manage, analyze, interpret, and transform data into accurate, consistent, and timely process information and knowledge. • Key liaison between PMPD and the Regeneron IT organization, partnering to ensure IT and OT short- and long-term strategies are aligned and enabling the next generation of process development by creating a comprehensive, unified vision and implementation plan for current and future systems and practices for data capture, analysis, management, and consumption. • Accountable for ensuring uninterrupted availability of PMPD's Operational Technologies supporting the data lifecycle, including OSIsoft PI Historian, GE UNICORN, FactoryTalk, Process Analytical Technology platforms, Internet-Of-Things (IOT) infrastructure and devices, and in-house applications. This includes software patching, incremental system growth, onboarding data sources, incident response, investigations, monitoring, process optimization, and training. • Responsible for forming the strategic vision for PMPD's Data Engineering efforts as the responsible lead for PMPD's data management steering committee, in close collaboration with PMPD Data Managers, PMPD Senior Management and Regeneron's IT organization. • Serves as a key liaison with all of PMPD's Data Governance teams, creates data communities within PMPD and cross-functionally provides coaching, mentorship, training, engagement and collaboration opportunities for PMPD Data Managers. • Partners with all Data Managers to ensure adherence to Data Integrity and Data Governance best practices. • Responsible for defining, implementing, disseminating and maintaining data standards/data dictionary in PMPD and ensure these align and are well integrated with similar efforts at Regeneron Corporation level. • Ensures internal and external customer needs are effectively met while developing relationships with customers that build trust and respect. • Familiarity with data and knowledge management platforms such as LIMS, RDBMS (Oracle, SQL Server), SharePoint, Electronic Lab Notebook, and Atlassian Confluence. • Familiarity with analytical and business intelligence tools such as TIBCO Spotfire, Power BI, R/RShiny, QlikView / Qlik Sense, and SAS JMP • Understands database design principles and experience in relational data modeling. Familiarity with data lake and/or data warehousing strategies desired. Supervisory Responsibility: • Provides leadership and a clear vision of Data Management direction and enables key reports to develop a successful plan to accomplish key objectives. Manages an efficient and effective team. • Coaches technical experts, performs resource planning, develops team structures and succession plans while also setting goals for self, direct reports and group or subgroup. • Holds team(s) accountable and provides ongoing, constructive feedback on performance and progress in light of expectations and group goals and guides responses to failures. • Recognized as leader and role model within department, inspiring teams within and outside department, developing team culture that is self-motivated, collaborative, and self-correcting, and communicating a compelling vision. • Demonstrated ability to facilitate positive change and history of creating structure for cross-functional teams and exhibit leadership in a matrix organization. Other Duties and Responsibilities: • Partners with groups throughout Regeneron to ensure PMPD Data Systems are current and well-integrated with the corporate data infrastructure. • Supports innovation and embraces change and change management required to bring new ideas to the forefront. • Thinks and acts proactively to sustain forward progress by the organization at large. • Collaborates across Regeneron by initiating partnerships and skillfully and constructively challenging group think. • Fosters continued optimization of data systems. • Effectively communicates vertically and horizontally with PMPD Management, IT partners, system owners, product owners, data engineers, and users. Possesses and utilizes excellent oral and written communication skills to successfully convey the strategic goals, approach, results and impact of efforts on new and improved data systems. Understands how to effectively position views and arguments appropriately to win support and inspire action. • Creates an environment where leadership and talent development are top priority, resulting in a high performing organization. Requirements: This position requires a minimum of a BS Degree + 15 years/MS Degree + 13 years/PhD years of relevant experience. Experience must include: • Strong understanding of manufacturing process development for biologics and underlying scientific and engineering principles as well as data sources (i.e. equipment), data aggregation and consumption needs. • In-depth understanding of systems architectural and communication standards including ANSI/ASI-95, OPC, DCOM, TCP/IP, and Industrial Ethernet. • Well versed in current Regulatory Requirements for Data Integrity and Industry best practices in Data Governance. • Experience with design, build, deploy of automation and execution systems, including OSIsoft PI Historian, synTQ for PAT, SCADA, Rockwell FactoryTalk, Kepware, and GE UNICORN. • Experience with common infrastructure, networking, observability, and security technologies such as Windows Servers, Amazon Web Services, VMWare, network load balancers, firewalls, New Relic, Splunk, Active Directory, Kerberos, and Secure Socket Layer (SSL). • Experience with change controls, software/system development life cycle (SDLC), Agile practices (Scrum and Kanban), DevOps, and toolsets and platforms such as Atlassian Jira, Bitbucket, Jenkins, and Docker. This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business. To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases. Summary: Purification and biochemical characterization of protein reagents and antibodies in support of the company's VelocImmune fully human antibody pipeline and Immune Oncology programs. Experience protein purification is required. This position will be primarily focused on purification of therapeutic reagents and antibodies for ongoing therapeutic programs using standard purification systems and some automated equipment. Database entry and documentation of purified characterized reagents in LIMS and power point reports is critical. Must be able to work productively in a fast-paced collaborative team environment. Excellent communication skills are essential. Responsibilities: Protein purification and characterization using liquid chromatography such as affinity, IEX, HIC, and SEC. Characterization of reagents by Western blotting, SDS PAGE electrophoresis, SEC chromatography, LAL, and concentration by UV. Protein conjugation of reagents with biotin, Alexa488, and PE, and other tags. Interpretation of results, documentation by ELN, and power point presentation slides for characterization and documentation of reagents and antibodies purified. Must be able to work productively in a fast-paced collaborative team environment. Excellent communication skills are essential. Requirements: Protein Purification by affinity, Ion exchange, and SEC chromatography Experience running the AKTA Explorer SDS Page Electrophoresis Western Blotting Sterile techniques Good Lab practices Spectrophotometry Data entry and notebook keeping using ELN #I-EG2 #dice This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business. To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

The Regeneron Genetics Center (RGC) is a wholly-owned subsidiary of the Company, whose goals are to apply large scale human genetics to identify new drug targets and to guide the development of therapeutics programs and precision medicine. Building upon Regeneron's strengths in mouse genetics and genetics-driven drug discovery and development, the RGC specializes in ultra-high-throughput exome sequencing, large scale informatics and data analysis encompassing genomics and electronic health records, and translating genetic discoveries into new biology and drug discovery opportunities. The RGC leverages multiple approaches including large population based studies, Mendelian genetics and family based studies, founder population genetics, and large-scale disease focused projects and has developed a network of over 50 collaborations with research organizations around the world. Including some of the largest sequencing studies in the world, such as the DiscovEHR study in collaboration with Geisinger Health System, and an initiative to sequence 500,000 participants with the UK Biobank, the RGC has built one of the largest human genetics databases, including sequence data from over several hundred thousand participants and rapidly growing. Our interests encompass a breadth of different areas across all therapeutic areas and the RGC is highly integrated into all facets of research and development at Regeneron. Program goals include target discovery, indication discovery, and patient-disease stratification. Objectives include advancing basic science around the world through public sharing of discoveries, providing clinically-valuable insights to physicians and providers of collaborating health-care systems, improving patient outcomes, and identifying novel targets for drug development. Summary: The overall goals of this position are to conduct analyses in founder and other unique populations, interpret genetic data in order to obtain a deeper understanding of human biology, bioinformatically support analysis and identification of novel targets, and seek indications for drug programs. The successful candidate will work as part of the Founder & Special Populations team as well collaborate with the RGC Analytical Genetics and Therapeutic Area Genetics teams to provide genetic, informatics, and biological support for genetics studies of founder and special populations. The successful candidate will: characterize the allelic architecture of many founder populations, provide bioinformatics support for family-based analyses, identify genes of potential interest through genotype-phenotype associations & other genetic approaches, harness internal & external data sources to better understand novel genetic findings, work with the Analytical Genetics group to seek validation of associations in other RGC population resources, and work with the Translational Genetics & Functional Modeling groups to glean deeper insights into mechanisms & biology. Responsibilities: • Ability to work collaboratively as a member of the Founder & Special Populations team, with other Regeneron teams, and with external collaborators • Manage multiple projects simultaneously and complete analyses in a timely & reliable manner • Catalog and interpret results of allelic architecture analyses in various founder populations to glean novel insights into human biology and develop follow-up strategies • Interpret results of genotype:phenotype association analyses from whole exome sequencing and genotyping studies • Apply biological insights, internal and external data sets, published literature, and other resources to prioritize genetic discoveries in founder and other unique populations for functional follow-up • Provide bioinformatics support for the Mendelian collaborations • Work with Analytical Genetics and Therapeutic Area Genetics teams to validate potentially interesting findings in founder and other special populations by extending the analyses to other RGC study populations (ex. Geisinger DiscovEHR, UK Biobank) • Work with Functional Modeling, Therapeutic Focus Area, and Early Clinical Development teams to nominate, design call-back studies, and functional experiments to follow-up on interesting hits • Summarize and communicate study findings to the Founder and Special Populations team, leadership, and internal and external collaborators • Survey the literature and attend conferences to incorporate discoveries and findings from the broader genetics community into study opportunities and considerations internally Requirements: • This position requires a PhD with 8+ years of experience with a strong background in human disease and/or applied population genetics • Some experience analyzing and interpreting whole exome sequencing and genotyping studies (ex. variant level QC, statistical association analysis, and interpretation of association signals in complex disease) • Some experience with standard statistical approaches and tools (ex. regression, linear mixed models, PLINK, R) and some programming experience (ex. Linux, Python) • Ability to summarize data and results to identify patterns, signals, and issues • An understanding of biology to integrate and leverage diverse datasets to identify interesting variants, genes, and genotype-phenotype associations • Experience with molecular characterization and functional studies geared towards elucidating gene functions and the mechanistic basis for genetic associations is a plus Level is commensurate with experience This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business. To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases. Summary: The position in the Therapeutic Target Discovery group will be responsible for developing and implementing technologies to aid the discovery of novel targets for a variety of therapeutic areas. These will contribute to our mouse phenotyping/ target discovery pipeline. This pipeline uses genetically modified mice to evaluate therapeutic potential of both novel and validated disease targets and identifies promising leads for follow up. We are seeking a highly creative and motivated scientist to discover new targets using cutting edge transcriptome based approaches and to create innovative new mouse genetic disease models. Expert scientific knowledge of one or more organ system/s and/or area/s of disease biology (and the methods of exploration of that system) as well as a background working with genetically modified mouse models is desireable. A solid general knowledge of developmental biology, and mouse genetics are highly desirable. This individual will have demonstrated abilities in the development of new methods or technologies to advance the understanding of biology. Responsibilities: • Develop genetic and in vitro transcriptomic methods to discover tissue/cell specific drug targets (e.g. TRAP-seq (ribosome or nuclear IP), Spatial transcriptomics, single cell sequencing, Slide-Seq, Site-Seq, laser microdissection etc...) • Optimize and/or develop new genetic reporter systems for evaluating gene expression of genes and signaling pathways • Develop genetic models of disease and drug activity (e.g. in vivo cell killing/ablation methods, conditional gene expression and deletion models, and/or genetic models of cancer) • Develop enhanced methods of constitutive (with reporter genes) or conditional gene deletion from ES or Zygote derived F0 cohorts (e.g. Crispr derived or enhanced targeting KO in ES cells or Oocytes) • Contribute to the development novel multiplexed imaging methods for RNA in situ and immunohistochemistry, proximity detection or related technologies. • The individual will have the opportunity to pursue interesting leads identified using these new methods. Requirements: The position requires a minimum of a PhD or MD with 0-6 years relevant postdoctoral experience. Additional requirements include: Expertise in molecular and cell biology, genetically modified mice and disease modeling and t the Ability to effectively organize and communicate data and to present to all levels, including supervisors and colleagues in other departments This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business. To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases. Summary: We are seeking a motivated Scientist with an advanced degree to join the Ophthalmology group for ocular immune and inflammatory diseases. This position will be part of a group responsible for studying pathogenic mechanisms in ocular immune diseases, the identification and validation of drug targets, and for the creation and testing of biologically based therapeutic agents against these targets. This position will work on in vitro and in vivo ocular inflammatory models for the group. This individual will be responsible for the design and execution of biological experiments necessary to develop animal models and deliver experimental therapeutic candidates. This individual will help evsluate therapeutic candidates with In Vitro and In Vivo experiments, and provide in-house technical expertise for interacting with external collaborators on research projects. The ideal candidate will be hardworking, flexible, innovative and able to function effectively in a fast-paced environment. They will also have excellent communication skills and be able to work well in a team. The preferred candidate will have at least 5 years of laboratory experience. Responsibilities: Design and perform cell culture using primary cell culture and cell lines Design and perform experiments in cellular and in vivo ocular immune and inflammatory disease models Collect and prepare tissue for histological or biochemical analyses Cut and stain ocular tissues, perform microscopy & image analysis Design and Perform cell culture assays for in vitro drug testing and screening Perform data analysis and prepare study report, and laboratory management duties Requirements: This position requires advanced degree, PhD and/or MD with at least 2 years post-doctoral experience. Experience with molecular biology and biochemistry techniques (preparation of cell/tissue for DNA/RNA/protein analysis, ELISA, Western blots, IHC, imaging) Five years of experience working with in vivo ocular immunology or inflammatory animal models preferred, experience with rodent ocular disease models highly desired. Strong organization and communication skills. This position will require the individual to pass a physical before beginning employment. This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business. To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law. 2 years post-doctoral work preferred This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business. To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases. Summary: Regeneron is seeking an experienced Preclinical Pharmacokinetics scientist who is well versed in the application of pharmacokinetics / pharmacodynamics (PK/PD), in order to describe and understand the pharmacology/biology of therapeutic proteins. The candidate will represent the Preclinical Pharmacokinetics and Pharmacodynamics (PPK/PD) group on cross-functional Discovery project teams and be an advocate for the use of quantitative approaches to describe the relationship between the known physiology and the observed pharmacokinetics of candidate drug molecules. This role will involve providing PK and PK/PD input into early preclinical in vivo studies, interfacing with scientific staff performing these studies, and preparing and presenting the PK/PD analyses to internal project teams and (potentially) senior management. This role will require a high level of collaboration across various functions within Regeneron; thus, the candidate must have the ability to influence, make decisions and have strong communication and leadership skills. The candidate will be expected to share his/her opinions, ask and answer challenging questions, and demonstrate tenacity, all in the context of excellent science, as Regeneron continues to create innovative new medicines. Responsibilities: • Serve on Discovery-stage project teams as a subject matter expert for Preclinical Pharmacokinetics/ Pharmacodynamics, providing PK or PK/PD input to the design of preclinical PK/pharmacology studies. • Collaborate effectively with various groups within Regeneron, including Therapeutic Proteins, Therapeutic Function Areas, Assay and Biomarker development, Preclinical Operations and PPK/PD management in order to develop a PK strategy for each project and then deliver the required output. • Effectively communicate project team queries, requests and expectations (i.e. timing and deliverables) from the Project Teams to staff and management. • Conduct and report PK and PK/PD analyses using data derived from preclinical studies. • Work in close association with the Toxicology, Pathology, as well as Clinical Pharmacology (CP) and Quantitative Pharmacology (modeling & simulation) functions, within the Drug Safety and Pharmacometrics (DSP) Department. • Maintain an up-to-date knowledge of the relevant scientific literature as well as regulatory guidances and best practices as they pertain to PPK/PD. Requirements: PhD in Pharmacology, Pharmacokinetics, Biology/Molecular Biology, Biochemistry or related Life-Science, with at least 6+ - 8+ years of relevant experience. • Previous experience with protein/ monoclonal antibody therapeutics in one or more of the following therapeutic areas - oncology, inflammation / immunology, metabolism, infectious disease or ophthalmology • In-depth theoretical and applied understanding of PK and PD, in order to describe and understand the pharmacology/biology of therapeutic proteins. • Demonstrated ability to plan, organize, oversee PK and/or PK/PD studies, and analyze PK/PD data • Excellent communication (written/verbal), presentation and leadership skills • Knowledge of and experience with relevant PK/PD software applications (eg, WinNonLin,) is desirable. • Demonstrated scientific creativity is required, together with the ability to propose innovative solutions. • Experience in writing PK reports, PK written summaries and contributing to IND's is desirable. This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business. To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases. Summary: Using scientific expertise and project management knowledge and experience, the Research Program Manager will proactively plans, coordinates, and leads cross-functional aspects of genetics projects supporting the Regeneron Genetics Center (RGC). A key responsibility is to support the RGC Therapeutic Area Genetics teams where a diverse set of technologies and approaches are being explored to identify new genetic associations that will help identify novel targets and drive strategies for treating relevant diseases. Job Duties: Drug and Technology Discovery & Development: Uses knowledge and experience in drug discovery and technology to steer and enable cross-functional therapeutic genetics teams to achieve key program objectives. In collaboration with other senior RGC and TFA group members, the program manager will formulate key program deliverables and implement operational practices to achieve these deliverables. Team Management: Independently ensures effective, accurate, appropriate and timely communication across functional areas within the project. Serves as the point of contact for management within and outside the team regarding progress and alignment with the program goals. Uses relevant working knowledge and experience to devise templates, working and best practices, and tracking and monitoring tools. Planning, Tracking & Project Reporting: Develops, maintains and updates integrated project plans relevant to team objectives and ensures alignment across functions and with management. Maintains knowledge of key data and milestones for assigned projects and serves as a contact for information and updates. Provides project summaries and general guidelines to support presentations to senior management and collaborators as needed. Process and Data Management: Manages and updates tools and program content to track projects and to promote a collaborative environment of scientific information exchange. Ensures effective, accurate and timely communication within the department or functional area. Defines and documents best practices and procedures by performing analyses and preparing recommendations. Identifies, develops and supports continuous improvement processes. Problem Solving: With minimal direction, the program manager will proactively identify potential issues and implement a mitigation strategies for general problem solving within the department or support areas. Requirements: This position requires a minimum of a BS with 8+ years / MS with 6+ years / or PhD with 2+ years of relevant experience. Relevant experience should include: Knowledge of project management techniques and concepts as they apply to the drug development / pharmaceutical industry. Demonstrates excellent written, verbal and interpersonal communication skills with the ability to effectively interact with team members with tact and diplomacy. Coordinates and provides direction for multiple projects and priorities with excellent time management skills. Proficient in relevant software such as Excel, PowerPoint, Word, etc. in addition to general knowledge of shared content work environments. The ideal candidate will be action oriented, organized, self motivated and able to lead teams through collaborative engagement. This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business. To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases. In this role, the Senior Manager will lead the development and execution of data management strategies and analytics for all development programs, including but not limited to Research and Global Development organizations. Additionally, this role will be a key player in driving the development and communication of KPIs related to said programs through a variety of dashboards, and they will develop and standardize the data models needed to achieve these objectives. Own and maintain the project management data model. Build enhancements and connectivity to new data sets, as they become available, in an efficient manner that follows industry standards and guidelines. Lead and support efforts around the creation of an integrated data management Leverage data to create business value. Support the team within DPM, and cross-functionally with other departments, around key existing/new applications used for the collection and maintenance of core data assets. Execute a strategy of "mine once and reuse". Ensure stewardship of data is clearly defined and adhered to by all departments and ensure there is overall strategy for the connectivity of company data to support vertical and horizontal integration across functional areas and organization Lead, direct and support efforts for all DPM internal applications in terms of clear strategy around purpose of existing applications and how they fit into the overall data management strategy from company-wide perspective Create, manage, and run core Development dashboards. Increase usage, create tools to manage data accuracy, and build reporting capabilities into key presentation Nature and Scope Operates cross-functionally and utilizes business and / or scientific knowledge and experience to contribute significantly to program reporting and knowledge management. Motivates, understands and builds effective teams. Regularly interacts with Sr. Management or executive levels on matters concerning KPI definition and reporting needs. Requires the ability to influence outcomes and change the thinking of, or gain acceptance of others in sensitive situations. Represents a department / organization or company in relevant internal / external committees. Errors in judgment or failure to achieve results would result in critical delays in schedules and/ or operations and may jeopardize overall business activities. Knowledge and Skills Education and Experience BS / MS with 8+ years of relevant progressive project management experience / data modeling / data visualization / knowledge management techniques. Advanced degree (e.g. PhD, MS plus MBA) preferred. Proficient in advanced techniques with relevant software: QlikView, Qlik Sense, SQL, SharePoint, Excel, PowerPoint, Word, etc. in addition to experience working within shared work environments. Extensive technical expertise in a discipline data modeling and knowledge management. Develops concepts, techniques and standards. A proven track record in data visualization. Strong leadership skills including meeting facilitation cross-functional team integration, strategic thinking and advising. Must be able to create an environment for collaborative work necessary for the team to be effective. Core competencies: Requires excellent written, verbal and interpersonal communication skills and the ability to effectively interact with all levels both within and outside the company to establish credibility with professionals on the project teams. Understands and motivates others and builds effective teams. Requires strong presentation and critical thinking skills. Proactively develops and fosters constructive interactions among team members to address difficult situations and guide how data is interpreted. Resolves and negotiates conflicts or problems with tact, diplomacy and composure. Handles multiple projects and priorities with exceptional organizational and time management skills (both project and self) Success Factors: Exhibits a degree of ingenuity, creativity and resourcefulness in a sometimes evolving and ambiguous environment. Shows resiliency in the face of challenges and adversarial situations. Exhibits confidence and a realistic sense of self awareness in own strengths and weaknesses. Builds bridges across the organization, and aligns how data is defined, interpreted, and displayed This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business. To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases. Summary: We are seeking a PhD level scientist to work in our Protein Development group. This position will be focused on expression and purification of proteins to support the efforts of Regeneron's structural biology group in X-ray crystallography and cryo-electron microscopy (cryoEM). The successful candidate will work closely with scientists in the structural biology group to develop purification procedures to deliver highly pure and homogeneous protein samples. Responsibilities: This work will be directed toward supplying the structural biology group with proteins or protein complexes for their research. In some cases, the expression and purification procedure will be straightforward, previously tested in house or in the scientific literature, in which case the priority will be to execute the procedure as cleanly and carefully as possible, so that the resulting sample will be pure and homogeneous, raising the odds of a successful structure determination. However, in many cases, there will be no clear path to follow. In these cases, the individual in this position will need to develop a new expression and purification procedure, drawing on available literature and previous experience, but then breaking new ground and using results from first attempts to refine the procedures for the next attempts. In the most challenging cases, we will be attempting things that may have never been done before. The proteins in question will be very diverse, including soluble proteins, integral membrane proteins, multi-protein complexes, antibodies, engineered constructs, etc. Most will be human in origin, and in most cases only the human protein will do - we will not have the luxury of testing other species for better behaved homologues. Integral membrane proteins will need to be solubilized using a variety technique drawn from the structural biology literature, including detergents, amphipols, and nanodiscs. In addition to purification, this position will involve protein expression using bacterial, insect, and mammalian cell systems. Innovation at this stage may save a lot of time in the purification stages, so this will be a key part of the job duties. Requirements: Candidates should have a PhD or equivalent degree in a discipline related to protein biochemistry. Postdoctoral experience and/or industry experience are not necessary but would be an advantage to the candidate. Prior experience in protein crystallization or cryoEM sample preparation is also not required but would be helpful. #LI-EG2 #dice The successful candidate should have a strong track record of protein expression and purification in a variety of projects. The structural biology samples to be worked on in this position will come from different expression systems, including bacteria, insect cells, and mammalian cells, and will include both soluble and membrane proteins. A candidate with experience across this spectrum will be preferred, although we do not expect any one person to have done all of this. The candidate should have experience with most standard protein purification techniques, including size-exclusion, ion exchange, and affinity chromatography, and protein characterization by SDS-PAGE and Western blotting. We will be looking for candidates with innovative ideas in protein biochemistry and a strong drive to succeed in challenging projects. Structural biology is very demanding in protein quality, and many proteins are difficult to express and purify to the necessary level. We want an individual who enjoys overcoming difficulties like these. This position will involve work on multiple projects simultaneously, so excellent record-keeping and time management skills are very important, as well as the ability to absorb new information rapidly. The candidate should be highly self-motivated and able to direct the course of their own work without extensive supervision. PhD in Biochemistry or related field This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business. To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases. Summary: We are seeking a highly motivated bioanalytical scientist who can contribute to the development and implementation of state-of-the-art quantitative and qualitative bioanalytical methods to support biopharmaceuticals, particularly antibody drug conjugates (ADC), in discovery and preclinical development pipeline at Regeneron. Job Duties: This position will be primarily responsible for developing LC-MS based bioanalytical methods in various biological matrices, in support of chemistry, PK/PD and TK studies, which will be used to quantitate biotherapeutic levels, detect and characterize in vitro stability and in vivo biotransformation, or measure biomarkers (small molecules, peptides and proteins), or for the characterization of drug candidates and critical reagents. The scientist will practice exceptional experimental design, data interpretation and the use of best practices including utilization of cutting-edge bioanalytical technologies, implementation of automation systems (as applicable), and adoption of standardized practices through basic understanding of relevant regulatory guidance. The scientist will generate analytical data to inform decision making and collaborate across different disciplines to advance ADC and other therapeutics programs. This individual is also expected to be involved with the assessment and implementation of innovative bioanalytical technologies and methods to meet the needs of an evolving portfolio that may include novel molecular modalities across a number of traditional and new therapeutic areas. Other duties include documenting experiments, results and findings in electronic notebook, presenting work at the internal/external meetings and keeping general lab and instrument maintenance. Additionally, this individual will serve as a bioanalytical representative on cross-functional project teams and effectively manage the prioritization to meet multiple project goals and timelines. Requirements: • Ph.D. in Chemistry, Biochemistry or a related field and 0-5 postdoctoral experience. Industrial experience in bioanalytical aspects of LC-MS based small molecule, biomarkers and biopharmaceutical assay development is preferred. • A strong background and extensive experience in liquid chromatography and mass spectrometry is required, with demonstrated track record of successfully developing LC-MS or LC-MS/MS methods on QQQ (Sciex or Waters preferred) and/or HR-MS (Q-TOF or Orbitrap) platforms. • Experience in sample preparation techniques (LLE, SPE, Immunocapture, Digestion etc) and automation platform. • Proficiency in mass spectrometry related software, such as Xcalibur, MassLynx, Analyst Biopharma finder, Proteome Discoverer, and other essential office/scientific software. Computer programming is a plus. • Strong capabilities in experimental design, execution and data interpretation with limited supervision. • Ability to think critically, anticipate and identify key issues and problem solving. • Excellent interpersonal and effective verbal and written communication skills. • Experience in ADC and/or oligonucleotides analytics and characterization, and basic knowledge in biochemical/cell-based assay is desired. • Previous experience in mass spectrometry application in lipidomics/metabolomics/proteomics would be advantageous. This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business. To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases. Summary: Purification and biochemical characterization of protein reagents and antibodies in support of the company's VelocImmune fully human antibody pipeline and Immune Oncology programs. Experience in protein purification is required. This position will be primarily focused on purification of therapeutic reagents and some antibodies for ongoing therapeutic programs. This position will generate nonstandard reagents that will require extra time and efforts for research support. Database entry and documentation of purified characterized reagents in LIMS and power point reports is critical. Must be able to work productively in a fast-paced collaborative team environment. Excellent communication skills are essential. Responsibilities: Protein purification and characterization using liquid chromatography such as affinity, IEX, HIC, and SEC. Characterization of reagents by Western blotting, SDS PAGE electrophoresis, SEC chromatography, LAL, and concentration by UV. Protein conjugation of reagents with biotin, Alexa488, and PE, and other tags. Interpretation of results, documentation by ELN, and power point presentation slides for characterization and documentation of reagents and antibodies purified. Must be able to work productively in a fast-paced collaborative team environment. Excellent communication skills are essential. Requirements: Protein Purification by affinity, Ion exchange, and SEC chromatography Experience running the AKTA Explorer SDS Page Electrophoresis Western Blotting Sterile techniques Good Lab practices Spectrophotometry Data entry and notebook keeping using ELN #LI-EG2 #dice This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business. To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases. Summary: We are looking for a highly motivated Ph.D. scientist to join the Therapeutic Antibody Luminex team. The successful candidate will directly contribute to the identification of potential therapeutic antibodies, bi-specific antibodies and other antibody modalities and selection process in early discovery stage. The scientist will design and develop protein multiplexing immunoassays using Luminex or other high through-put technologies; compile multifaceted screening data and report finding to a cross-functional team. The candidate should have a strong background in biological sciences preferable biochemistry or immunology with hands-on experience in immunoassay development. Excellent interpersonal and communication skills are required, as this candidate will be expected to work productively in a collaborative, cross-functional team environment. Critical thinking and ability to maintain a high level of productivity in a fast-pace, deadline driven project-oriented team environment is essential. Responsibilities: • Design and optimize high-throughput multiplexing immunoassay to asses antibody therapeutic binding properties. • Design and execute antibody binding characterization and profiling using Luminex technology or other immunoassay platforms. • Explore and provide information on new bead-based screening technologies and expand the scope of the existing technologies • Organize and carry out high through put screenings according to target-specific antibody screening plans. • Summarize experimental results and inform the project team timely and present the results in inter-department working meetings. • Work successfully in cross-functional teams either as team member or as independent contributor. • This Scientist position comes with the potential to manage Research Associates Requirements: • A PhD in a related field of study • A minimum of two years of post-graduate degree with extensive knowledge of immunology and hands-on bench research/development experience required. • Experience in in-vitro protein characterization, such as chemical and/or enzymatic protein modification and protein structure-function relationship in the field of biochemistry or immunology is required. • Experience with in multiplexing screening using Luminex or other technologies (label-free sensor technology) is highly desirable. • High throughput screening and familiarity with automated systems are beneficial. • Experience using word processing, spreadsheet and graphical analysis software required. • Must be able to multitask and perform rigorous data analysis under time pressure. • Ideal candidate should have experience working as independent researcher as well as collaborative team member and communicate effectively within large team. • Excellent adaptability and flexibility are essential. #I-EG2 #dice This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business. To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases. The Molecular Profiling group is looking for a talented data scientist with experience in genomic data analysis and algorithm development. The scientist will analyze preclinical and clinical data to support target and biomarker discovery & validation, as well as develop statistical and computational methods to advance our understanding of complex biological systems. Develop computational methodologies to integrate and model multi-modal data to help address the gap in understanding new molecular biology. Work with leadership to identify novel therapeutic targets and biomarkers via mining proprietary pre-clinical and clinical data. Develop data analysis pipelines and establish data analysis best practices for emerging genomic technologies. Collaborate with colleagues in research to design experiments and define data analysis plans. Communicate results with collaborators, refine analysis based on feedback. Prepare clear, concise and easy-to-understand presentations and documentations for collaborators, senior management and government agencies. #LI-GP1 Requirements: PhD + 0-3 years minimum in computational biology, biomedical engineering, bioinformatics, applied mathematics, or related quantitative field, with a track record of high quality publications Experience in analysis, interpretation, and visualization of sequencing data (e.g. bulk/single-cell RNA-seq, CRISPR screening) Expertise in statistical data analysis and algorithm development High proficiency in analytical and programming tools such as Python and R, and their associated packages for statistics, modeling and visualization Hands-on experience in machine learning, predictive modeling, and/or image analysis is highly preferred Familiarity with Unix/Linux, shell scripting, SGE clusters, AWS environment Proven problem-solving skills and collaborative nature in fast-paced environment. Ability to work both independently and collaboratively Excellent communication and presentation skills This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business. To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law. #LI-GP1

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases. Summary: Using scientific expertise and project management knowledge and experience, the Associate Manager, Research Program Management plans, coordinates, and leads cross-functional and operational aspects of the drug discovery process, from early-discovery through early clinical development. A key responsibility is to support the Therapeutic Focus Area groups where a diverse set of technologies and approaches are being explored to identify new targets and to develop strategies for treating relevant diseases. A scientific background in Neuroscience or a related field is preferred. Drug and Technology Discovery & Development: Uses knowledge and experience in drug discovery and technology to steer and enable cross-functional teams to achieve key program objectives. In collaboration with other senior group members, formulates key program deliverables and implements operational practices to achieve these deliverables. Team Management: Ensures effective, accurate, appropriate and timely communication across functional areas within the project. Serves as point of contact for management within and outside the team regarding progress and alignment with the program goals. Uses relevant working knowledge and experience to devise templates, working and best practices, and tracking and monitoring tools. Planning, Tracking & Project Reporting: Develops, maintains and updates integrated project plans relevant to team objectives and ensures alignment across functions and with management. Maintains knowledge of key data and milestones for assigned projects and serves as a contact for information and updates. Provides project summaries and general guidelines to support presentations to senior management and collaborators as needed. Process and Data Management: Manages and updates tools and program content to track projects and to promote a collaborative environment of scientific information exchange. Ensures effective, accurate and timely communication within the department or functional area. Defines and documents best practices and procedures by performing analyses and preparing recommendations. Identifies, develops and supports continuous improvement processes. Problem Solving: Identifies opportunities and develops tools and mechanisms for monitoring progress and for general problem solving within the function or department. Requirements: This position requires a minimum of a PhD with 2 years of relevant experience, or a BS/MS with a minimum of 7 years of relevant experience in technology and drug discovery and development. This experience should include knowledge of project management techniques and concepts as they apply to the drug development / pharmaceutical industry and/or hands-on laboratory experience (biology, molecular biology, biochemistry, or a related field) preferred. Desired attributes: Action oriented, organized, and able to lead teams through collaborative engagement. Demonstrates excellent written, verbal and interpersonal communication skills with the ability to effectively interact with team members with tact and diplomacy. Coordinates and provides direction for multiple projects and priorities with excellent time management skills. Proficient in relevant software such as Excel, PowerPoint, Word, etc. in addition to general knowledge of project management software and shared content work environments. This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business. To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases. Summary: The Clinical Pharmacologist role provides clinical pharmacology (CP) expertise to programs across all stages of drug development. The Clinical Pharmacologist is responsible for delivering comprehensive CP strategic development plans and applying quantitative-based methodologies to optimally support drug development programs. Responsibilities: • Contribute to and/or develop comprehensive CP strategic development plans for assigned development programs • Provide CP subject matter expertise to clinical study and project development teams in the design, conduct, and reporting of clinical trials for development programs in both early and late development • Integrate knowledge of PK/PD, patient covariates, and disease state to optimize dose selection, dosage regimens, and study designs throughout the different stages of drug development • In collaboration with Quantitative Pharmacology, develop and deliver modeling & simulation (M&S) strategies to support assigned development plans and inform key drug development decisions/milestones • Supervise and/or conduct PK, PK/PD, and dose/exposure-response analyses in both early and late development • In collaboration with preclinical PK/PD, translate preclinical data to support human PK and efficacious dose projections; provide scientific justification for optimal human starting dose and dose escalation schemes for FIH studies • Contribute to and/or author CP sections of clinical study protocols, study analysis plans, CP study reports, clinical development plans, and scientific publications • Contribute to and/or provide regulatory strategy for CP, prepare CP contributions to regulatory documents including Investigator Brochures, IND's, briefing books, BLA and MAA submissions, post-approval filings, and responses to health authority questions, and where appropriate, represent CP in relevant external regulatory meetings (EOP2, pre-BLA/MAA, Advisory Committee meetings) • Stay abreast of new developments in CP, drug development, regulatory, and M&S by publishing in peer-reviewed journals, attending and presenting scientific data at conferences, and participating in special interest groups within professional societies • As appropriate, participate in the evaluation of potential business development opportunities Requirements: • PhD in Pharmaceutics, Biology, Pharmacology, Engineering, Pharmacy (Pharm.D.), Medicine (MD) • 5 plus years of industry or equivalent experience in CP and/or clinical PK/PD • Ability to analyze and critically assess PK/PD data; proficient in PK/PD software eg, WinNonlin, R, NONMEM, Monolix • Demonstrated ability to work in a collaborative, cross-functional team environment • Excellent verbal and written communication skills • Self-motivated, able to work independently Preferred Qualifications • Prior experience in PK and PK/PD of large molecule (eg, monoclonal antibodies, bispecifics, fusion proteins, antibody-drug conjugates) and/or RNA therapeutics • Prior CP experience in infectious disease, neuroscience, or ophthalmology drug development is desired This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business. To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases. Summary Regeneron is seeking an experienced Preclinical Pharmacokinetics (or Pharmacology) scientist who is well versed in the application of pharmacokinetics / pharmacodynamics (PK/PD), in order to describe and understand the pharmacology/biology of therapeutic proteins. The candidate will represent the Preclinical Pharmacokinetics and Pharmacodynamics (PPK/PD) group on cross-functional Discovery project teams and be an advocate for the use of quantitative approaches to describe the relationship between the known physiology and the observed PK/PD of candidate drug molecules. This role will involve providing PK and PK/PD input into early preclinical in-vivo studies, interfacing with scientific staff performing these studies, and preparing and presenting the PK/PD analyses to internal project teams and (potentially) senior management. Additionally, interaction with Clinical Pharmacology and Early Clinical Development staff will be necessary as these data will be used to support dose selection for early clinical trials. This role will require a high level of collaboration across various functions within Regeneron; thus, the candidate must have the ability to influence, make decisions and have strong communication and leadership skills. The candidate will be expected to share his/her opinions, ask and answer challenging questions, and demonstrate tenacity, all in the context of excellent science, as Regeneron continues to create innovative new medicines. Responsibilities • Serve on Discovery-stage project teams as a subject matter expert for Preclinical Pharmacokinetics/ Pharmacodynamics, providing PK or PK/PD input to the design of preclinical PK/pharmacology studies. • Collaborate effectively with various groups within Regeneron, including Therapeutic Proteins, Therapeutic Function Areas, Assay and Biomarker development, Preclinical Operations and PPK/PD management in order to develop a PK strategy for each project and then deliver the required output. • Effectively communicate project team queries, requests and expectations (i.e. timing and deliverables) from the Project Teams to subordinates and management. • Conduct and report PK and PK/PD analyses using data derived from preclinical studies. • Work in close association with the Toxicology, Pathology, Clinical Pharmacology (CP) and Quantitative Pharmacology (modeling & simulation) functions, within the Drug Safety and Pharmacometrics (DSP) Department. • Maintain an up-to-date knowledge of the relevant scientific literature as well as regulatory guidances and best practices as they pertain to PPK/PD. Requirements PhD in Pharmacology, Pharmacokinetics, Biology/Molecular Biology, Biochemistry, with at least 6+ years of relevant industry experience. • Previous experience with protein/monoclonal antibody therapeutics in one or more of the following therapeutic areas - oncology, inflammation / immunology, metabolism, infectious disease or ophthalmology - is required. • In-depth theoretical and applied understanding of PK and PD, in order to describe and understand the pharmacology/biology of therapeutic proteins, is required. • Demonstrated ability to plan, organize, oversee PK and/or PK/PD studies, and analyze PK/PD data is essential. • Excellent communication (written/verbal), presentation and leadership skills are required. • Knowledge of and experience with relevant PK/PD software applications (e.g., WinNonLin,) is desirable. • Demonstrated scientific creativity is required, together with the ability to propose innovative solutions. • Experience in drafting PK reports and IND's is desirable. This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business. To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law. #INDSTAT

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases. Position 1: The student will utilize the state-of-the-art mass spectrometry (MS) technology to develop and optimize analytical methods for biochemical characterization of antibody-based therapeutic proteins. The student will have the opportunities to learn and execute different LC-MS based methods (intact mass, peptide mapping, N-glycan analysis, and etc.) for primary structure analysis, disulfide bond linkage determination, carbohydrate profiling, and post-translational modifications identification on monoclonal antibodies. Position 2: The student will learn and use different liquid chromatography-mass spectrometry (LC-MS) instrument to support protein identification and quantitation. He/she will work together with mentor to develop or improve analytical method for host cell protein analysis using Q Exactive plus or Q-TOF MS. He/she will handle sample preparations in wet lab for proteomics experiments. Student responsibilities include but are not limited to: 1. Prepare samples and setup instruments for LC-MS analysis; 2. Analyze data using bioinformatics tools; 3. Write results and summary in Word and PowerPoint format; 4. Present results/updates in team and group meetings. Position 3: The summer intern will work on the method development of hybrid ligand binding-LC-MS/MS assays for the bioanalysis of antibody drug conjugates (ADCs). The intern will also transfer the manual sample preparation method to an automated liquid handling workstation. The intern will have opportunities to gain the knowledge of drug development processes. The intern will be expected to design and execute experiments in an efficient, well documented, and organized manner. Position 4: The student will have the opportunities to learn about AC and related technology, with a focus on fundamentals of HPLC and MS and their applications on supporting biopharmaceutical developments. The student will work closely with our experienced industry-leading scientists to learn cutting-edge analytics, including size exclusion chromatography, ion exchange chromatography, affinity chromatography, Orbitrap mass spectrometry, design of experiment, analytical sample prepartion workflow and data anlaysis etc. The student will assist in fractionation of protein aggregates, charge variants and investigate the impact of these species on antibody-Fc receptors interactions by functional mass spectrometry. This study can provide the insight on how the size and charge variants could alter antibody-dependent cell-mediated cytotoxicity(ADCC), complement dependent cytotoxicity (CDC) and neonatal Fc receptor (FcRn)-mediated recycling." Position 5: The intern will work in a state-of-the-art MS laboratory to develop and optimize analytical methods for biochemical characterization of monoclonal antibodies. The student will learn and apply liquid chromatography mass spectrometry (LC-MS) methods to analyze protein primary structure, identify disulfide bond linkages, profile carbohydrates, determine protein variant structure, and identify post-translational modifications. The intern will document experiments and finding in a laboratory notebook. The student is expected to present their work to AC department at the end of their program. Position 6: The student will be working in state-of-art MSlab and developing bottom-up MS strategies for Host Cell Protein analysis. Therefore, hands-on experience with proteomics techniques (MS, affinity chromatography) and software (skyline, proteome discover) is desired. Position 7: The intern will work in a state-of-the-art MS lab and learn analytical methods for therapeutic protein product analysis. The individual will focus on biochemical characterization of therapeutic proteins by learning and applying liquid chromatography mass spectrometry (LC-MS) methods to analyze protein primary structure, identify disulfide bond linkages, profile carbohydrates, determine protein variant structure, and identify post-translational modifications. Position 8: The student will develop and apply LC-MS based technologies to study non-specific interactions between monoclonal antibody (mAb) drug product and serum proteins, which can potentially lead to protein aggregation and/or particulate formation. The selected student will have the opportunity to work in an industry leading analytical team, and evaluate a variety of state of the art mass spectrometer platforms (Thermo Orbitrap, Waters Xevo G2S, Ab Sciex Triple TOF, etc) for desired applications. The position will also provide the student good opportunity to learn about the monoclonal antibody drug development as well as the critical role of analytical characterization in developing highly safe and effective biologic drugs. The intern will contribute to the following aspects with minimal supervision to deliver the project: 1) build in vitro model system of antibody particulate formation upon plasma exposure based on literature report; 2) develop and apply LC-MS based proteomic approach to profile the plasma proteins involved in the non-specific interaction and particulate formation; 3) screen REGN mAbs, formulation buffers and/or IV diluents to understand individual role of protein sequence and matrix in the particulate formation; 4) summarize and present the results to the team and Analytical Chemistry department at the end of internship Successful candidate will have stronge interest in therapeutic antibody drug development, and creativity in new technology development. He/she should also have hands-on experience with common LC-MS/MS instrument platforms and data processing software. Position 9: The student will expand the analytical capabilities of the AC group through the development and optimization of ultraviolet photodissociation (UVPD) based mass spectrometric methods to support the structural characterization of Regeneron's therapeutic molecules. UVPD-MS, which entails irradiating gas phase ions with UV photons to promote high energy fragmentation followed by subsequent mass analysis, has emerged as a powerful analytical tool for deriving structural information from proteins and protein complexes. For this project, the student intern will focus on the development of a UVPD-MS platform for middle-down and top-down analysis of monoclonal antibodies (mAbs) using a state-of-the-art Orbitrap mass spectrometer equipped with a 213 nm UV laser. The student will systematically optimize UVPD parameters for the elucidation of mAb primary sequence and post-translational modifications, as well as establish a robust data analysis workflow to support analytical characterization at the top-down and middle-down levels. Start building your skills at Regeneron. • Must be pursuing a Bachelor's, Master's or PhD • Must be pursuing a degree in Chemical Engineering, Biomedical Engineering, Chemistry, Analytical Chemistry, Biology, Biochemistry, Biotechnology, or related field • Must have experience with Mass Spectrometry (MS), Liquid Chromatography (LC), and Protein Chemistry • Experience with proteomics and immunoprecipitation is preferred • Experience with data processing software • Must have strong organizational, communication, and interpersonal skills with the ability to troubleshoot General Intern Program Information: • Must be enrolled in, or accepted to, an academic program pursuing a Bachelor's, Master's, PhD or PharmD • Summer Program is full-time (~40 hrs/wk) for at least 10 weeks and is paid • Prefer demonstrated leadership in areas such as campus activities, clubs, sports or the community • Minimum GPA of 3.0 • You will work with a specific manager on a project(s) • Enjoy weekly 1 hour Intern Program events: learn about other areas of the company from VPs and other employees, soft skills workshops, networking, volunteering, and more! • Present to your team on your summer project Transportation and Housing: • Housing stipend available for those students who meet mileage requirements • A free shuttle is offered from the North White Plains or Tarrytown train stations to the Tarrytown, NY or Sleepy Hollow, NY campuses • Get to know other incoming Interns on our closed LinkedIn page when you accept an offer This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business. To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid. ..... click apply for full job details

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases. Summary: This role is primarily responsible for all aspects of histology in the Skeletal Diseases group, from processing fresh tissue through creating reports that outline, summarize and interpret results. Additionally, this role is responsible for ensuring all samples and data are catalogued and easily obtained by a variety of employees within the R&D area. This position will also include conducting in vivo experiments and in vitro assays of samples. The ideal candidate will be flexible, innovative and able to function effectively in a fast-paced environment. Responsibilities: • Designs and executes histology processing and other experiments based on protocols provided by literature, seminars, and other scientific staff. Specifically, in this role, this majority of the role is focused on processing of fresh tissues, paraffin sectioning, routine histological staining (willing to train), immunohistochemistry, RNA scope, slide scanning, sample and slide cataloguing, analyzing and collating data • Requires the ability to work independently, having excellent mastery of the technical skills in the above field, a knowledge of proper controls, an ability to develop a research strategy, and evidence of a creative and critical approach to scientific problem solving. • Must be capable of organizing efforts, correcting the plan based upon results and eventually reporting the results to management either verbally or in writing. • Learns safety requirements of his/her laboratory. Attends safety training. Participates as a member of laboratory safety committees as assigned. Maintains complete and accurate laboratory safety records consistent with company and legal requirements. Recognizes potential safety problems and takes action to correct them. • Suggests modifications to protocols or alternative protocols. • Introduces new ideas on how to design, execute, and analyze particular experiments. • Effectively and independently operates a range of laboratory instrumentation. • Capable of managing time effectively • Reads and begins to critically evaluate the literature in a specialized scientific field. Secondary Duties and Responsibilities include, but are not limited to, the following: • Running of other assays in the lab such as Western, ELISAs, FACS, cell culture when needed. • Helping with in vivo studies. • Participates effectively as a team member within his/her own laboratory. Works effectively with people in other laboratories. • Maintains cleanliness in own work area and in communal work areas. • Maintains stocks of supplies and maintains equipment. • Communicates with appropriate laboratory support personnel. #INDSTAT Requirements: Minimum of a Bachelor's degree (B.A.) from an accredited college or university and seven (7) years of post-degree laboratory experience necessary. An MS degree is also acceptable. Experience with all aspects of histology is essential, prior experience with histology of bone would be desirable. This role is responsible for processing, sectioning, staining and analyzing samples obtained from murine models. Experience with animal experimentation (dosing, implants, surgeries, fluid and tissue collection), maintaining tissue repositories and molecular assays (e.g. ELISA) is highly desirable. Additional requirements include maintaining equipment, documentation, analyzing and providing regular updates of experiment results Presents concise activity summaries at work group meetings. Maintains electronic laboratory notebooks in accordance with company policy and legal requirements. Research Specialists at this level are required to be independent in the execution of experiments. Their ability to design experiments and interpret results allows them to increasingly pursue projects that incorporate a more diverse set of skills. This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business. To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases. Summary: We are interested in establishing a small genetics core group, using zebrafish as a model organism. We are seeking a highly motivated and experienced scientist to help establish this group, and to drive our discovery and development efforts pertaining to mechanisms induced from in vivo biological experiments, applying target and therapeutic questions to the zebrafish model. It will be necessary to help establish and guide a small group of people to work collaboratively in developing the vision for future studies. Specific work will be around developing genetic models for testing of experimental therapeutics and for mechanistic biology studies, by also establishing innovative ways to study these models.. The secondary objective of this role is to provide outstanding scientific and people leadership, in addition to planning and management of in vivo, pre-clinical science, to a new team of researchers focused on target discovery and validation efforts across a wide range of areas in the various therapeutic areas, by applying the zebrafish approach. This role includes overseeing the non-clinical evaluation of drug candidates in animal models; establishing and validating animal models that are relevant for understanding mechanisms of aging, cardiovascular disease, neurological disease, fibrosis, etc that may give rise to, or create a permissive environment for, human clinically-relevant disorders. The team has access to REGN's industry leading and proprietary technologies for target validation (VelociGene and VelociMouse), antibody generation (VelocImmune) and protein production (VelociMab) to support rapid target discovery and validation efforts. Responsibilities: o Provides scientific leadership in understanding new biology and mechanisms of vulnerability which can be tested and modelled in zebrafish. o Provides strategic and innovative scientific leadership to achieve the Core Zebrafish goals in conjunction with Sr. Scientific management input and direction o Manages and coordinates non-PhD scientific staff in the execution and design of experiments to discover and validate new targets within the various therapeutic realms, including establishing aged pre-clinical models, and disease models. o Has primary and direct responsibility for evaluating the results of ongoing studies and sets clear priorities across the core group, to progress the best drug targets and candidates into the clinic o Interacts with and presents to other groups in Discovery Research and Sr. Scientific management to inform them of progress, invite collaboration and to provide an in-depth review of the science o Works collaboratively and openly invites scientific questioning from peers and the TFA teams alike o Provides high quality and timely reports to support pre-IND and post IND activities and /or government agencies as needed o Develops scientific team members in their ability to evaluate data critically, design experiments, present data in audience appropriate ways, and to ready our next generation of scientific talent for potential broader scientific and/or people leadership roles. Contributes to the REGN post doc program as needed/ o Establishes and leads extramural collaborations o Writes and/or supports writing of manuscripts for publication in peer reviewed journals by the team o Drives scientific rigor and innovation throughout the TFAs through keeping current on scientific topics and discoveries through literature review and conference attendance; ensures that the team does the same and new data and approaches are incorporated into the TFAs as appropriate Requirements: This position requires a minimum of a PhD/MD with at least 3 years of relevant academic and /or industry experience leading teams, focused on using zebrafish as a preclinical model. Some prior experience in muscle disease is helpful but not required. Some experience in industry is preferred. A proven track record of innovation via discoveries and publications that underscore his/her ability to understand the biology and mechanisms of vulnerability to age-related signaling changes. The ideal candidate will have in-depth in vivo technical expertise, be hardworking, flexible, innovative and able to function effectively in a fast-paced environment. They will also have excellent communication skills and be able to work well in a team. This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business. To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.