Frederick National Laboratory for Cancer Research

Frederick National Laboratory for Cancer Research Frederick, MD, USA
Sep 18, 2020
Full time
PROGRAM DESCRIPTION The Clinical Services Program's primary mission is to perform sequential studies using samples obtained from patients with cancer, AIDS, chronic granulomatous disease or other diseases associated with immunologic dysfunction, as well as to monitor viral load in patients with HIV. The Vaccine, Immunity and Cancer Program investigates immune responses to vaccines in preclinical and clinical studies, with a focus on HPV. KEY ROLES/RESPONSIBILITIES The Vaccine, Immunity and Cancer Program is looking for a Research Associate to work on serology assay development and testing for SARS-CoV-2. The Research Associate will produce critical assay reagents, assay standards and perform testing for assessment of immune responses to viral infection. The Research Associate will: Optimize and validate procedures and methodologies for assessment of antibody responses to viral infection Plan experiments and conduct testing of large number of samples from...
Frederick National Laboratory for Cancer Research Bethesda, MD, USA
Sep 18, 2020
Full time
Program Description: The Applied and Developmental Research Directorate (ADRD) provides clinical and biological monitoring, regulatory support, biospecimen processing and storage, assay development, and project management support to the National Cancer Institute (NCI) and National Institute of Allergy and Infectious Disease (NIAID) clinical programs including Division of Cancer Treatment and Diagnosis (DCTD). DCTD facilitates pathways of unique molecules, diagnostic tests, and therapeutic interventions to clinical applications, including distinct molecular signatures for cancer, refined molecular assays, and state-of-the-art imaging techniques KEY ROLES/RESPONSIBILITIES The Secretary I will: Provide procurement support to DCTD laboratory staff using blanket orders, purchase requisitions, credit card, and online warehouse system. Data entry into appropriate financial system component (CostPoint, Cor360), status checks on orders, reconciliation of credit card transactions,...
Frederick National Laboratory for Cancer Research Frederick, MD, USA
Sep 18, 2020
Full time
The Information Security and Compliance Office (ISCO) is a part of the Enterprise Information Technology (EIT) Directorate within Leidos Biomed. The ISCO provides IT security auditing, engineering, and incident response support for the Frederick National Laboratory for Cancer Research (FNLCR) and the National Cancer Institute - Frederick. The mission of the Information Systems Program is to develop an enterprise-level, consolidated information technology infrastructure that provides exceptional IT capabilities to the Frederick National Labs for Cancer Research (NCI-Frederick/FNLCR) in support of basic, translational, and clinical cancer and AIDS research. ISCO supports the life cycle of information security for the scientific mission and administrative functions of the NCI-Frederick/FNLCR, to ensure the availability of information systems, protect the integrity of information, and protect the confidentiality of intellectual property and patient data. KEY ROLES/RESPONSIBILITIES...
Frederick National Laboratory for Cancer Research Rockville, MD, USA
Sep 16, 2020
Full time
The Frederick National Laboratory is dedicated to improving human health through the discovery and innovation in the biomedical sciences, focusing on cancer, AIDS and emerging infectious diseases. With leading science and technology, the laboratory performs basic research, supports clinical trials and drug development, develops and applies next-generation technologies to solve applied problems while serving as a national resource of high-tech facilities, while also effectively responding to emerging health threats. The Biomedical Informatics and Data Science (BIDS) directorate works collaboratively and helps to fulfill the mission of Frederick National Laboratory in the areas of biomedical informatics and data science by developing and applying world leading data science and computing technologies to basic and applied biomedical research challenges, supporting critical operations, developing and delivering national data resources, and employing leading-edge software and data...
Frederick National Laboratory for Cancer Research Bethesda, MD, USA
Sep 15, 2020
Full time
PROGRAM DESCRIPTION The Laboratory Animal Sciences Program (LASP) provides exceptional quality animal care and technical support services for animal research performed at the National Cancer Institute at the Frederick National Laboratory for Cancer Research. LASP executes this mission by providing a broad spectrum of state-of-the-art technologies and services that are focused on the design, generation, characterization and application of genetically engineered and biological animal models of human disease, which are aimed at the development of targeted diagnostics and therapies. LASP contributes to advancing human health, developing new treatments, and improving existing treatments for cancer and other diseases while ensuring safe and humane treatment of animals. The Molecular Histopathology Laboratory (MHL) within LASP provides comprehensive research support for the FNLCR/NIH on a fee for service basis. Offerings include hematology and blood chemistry testing, animal necropsy,...
Frederick National Laboratory for Cancer Research Rockville, MD, USA
Sep 15, 2020
Full time
The mission of the Biomedical Informatics and Data Science (BIDS) directorate is to leverage leading-edge data science, informatics and information technology skills and capabilities to provide the world-class tools and services to accelerate translation of biomedical data to scientific discoveries, medical treatments, and diagnostic and prevention innovations for cancer and AIDS patients. The BIDS Strategic and Data Science Initiatives Group has been established within the BIDS directorate to undertake key initiatives and establish new collaborations in computing and data science to address cancer challenges and accelerate cancer research. A key focus of this group is to provide secure and robust data management platforms and services for scientific data in accordance with FAIR data principles supporting an increasing level of analysis for the ever-expanding collection of scientific datasets. KEY ROLES/RESPONSIBILITIES This position description does not represent a current...
Frederick National Laboratory for Cancer Research Bethesda, MD, USA
Sep 14, 2020
Full time
Within Leidos Biomedical Research Inc., the Clinical Research Directorate (CRD), various clinical support teams provide high-quality comprehensive and strategic operational support to the high-profile domestic and international clinical research initiatives of the National Cancer Institute (NCI), National Institute of Allergy and Infectious Diseases (NIAID), Clinical Center (CC), National Heart, Lung and Blood Institute (NHLBI), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Center for Advancing Translational Sciences (NCATS), National Institute of Neurological Disorders and Stroke (NINDS), the National Institute of Mental Health (NIMH) and the National Institute of Environmental Health Sciences (NIEHS). CRD's support services are strategically aligned with the program's mission to provide comprehensive, dedicated support to assist National Institutes of Health (NIH) researchers in providing the highest quality of clinical research in...
Frederick National Laboratory for Cancer Research Frederick, MD, USA
Sep 14, 2020
Full time
The Laboratory Animal Sciences Program (LASP) provides exceptional quality animal care and technical support services for animal research performed at the National Cancer Institute at the Frederick National Laboratory for Cancer Research. LASP executes this mission by providing a broad spectrum of state-of-the-art technologies and services that are focused on the design, generation, characterization and application of genetically engineered and biological animal models of human disease, which are aimed at the development of targeted diagnostics and therapies. LASP contributes to advancing human health, developing new treatments, and improving existing treatments for cancer and other diseases while ensuring safe and humane treatment of animals. KEY ROLES/RESPONSIBILITIES Resolving issues pertaining to laboratory animal husbandry, health and welfare. Provide managerial oversight of the Receiving and Quarantine Program & Veterinary Associates. Perform administrative and...
Frederick National Laboratory for Cancer Research Bethesda, MD, USA
Sep 13, 2020
Full time
The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community and provides dedicated support to NCI's intramural Center for Cancer Research (CCR). The dedicated units provide expertise in electron microscopy, protein characterization, mass spectrometry, protein expression, optical microscopy and genomics. These research efforts are an integral part of CCR at the Frederick National Laboratory for Cancer Research (FNLCR), where CRTP scientists work collaboratively with intramural NCI investigators to provide research technologies and expertise KEY ROLES/RESPONSIBILITIES We are seeking a highly motivated Research Associate II/III to join the Single Cell Analysis Facility (SCAF) of the Center for Cancer Research (CCR) at NCI. The SCAF provides support for...
Frederick National Laboratory for Cancer Research Bethesda, MD, USA
Sep 12, 2020
Full time
Within Leidos Biomedical Research Inc., the Clinical Research Directorate (CRD), various clinical support teams provide high-quality comprehensive and strategic operational support to the high-profile domestic and international clinical research initiatives of the National Cancer Institute (NCI), National Institute of Allergy and Infectious Diseases (NIAID), Clinical Center (CC), National Heart, Lung and Blood Institute (NHLBI), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Center for Advancing Translational Sciences (NCATS), National Institute of Neurological Disorders and Stroke (NINDS), the National Institute of Mental Health (NIMH) and the National Institute of Environmental Health Sciences (NIEHS). CRD's support services are strategically aligned with the program's mission to provide comprehensive, dedicated support to assist National Institutes of Health (NIH) researchers in providing the highest quality of clinical research in...
Frederick National Laboratory for Cancer Research Frederick, MD, USA
Sep 12, 2020
Full time
The Laboratory of Human Retrovirology and Immunoinformatics (LHRI), Clinical Services Program, Applied/ Developmental Directorate, has investigated the mechanism of multiple drug resistance (MDR) in HIV-infected patients using techniques of molecular biology , virology , cellular biology and bioinformatics under a collaboration with the National Institute of Allergy and Infectious Diseases (NIAID)/NIH . Our goal is to develop novel immune therapy for MDR-infected patients who have failed from current available chemotherapies. LHRI has isolated several mutants of novel MDR HIV and characterized drug-resistant profiles and discovered Interleukin-27 and Interferon-lambda1 as novel anti-MDR cytokines, SPTBN1(in macorphages) and YB-1 (in T cells) as host essential factors for virus infection, which are potential novel drug targets, a total of 72 novel micro RNAs (miRNAs) possessing anti-viral/tumor properties and 44 novel long none-coding RNAs (LncRNAs) of unknown function (LncRUF)....
Frederick National Laboratory for Cancer Research Frederick, MD, USA
Sep 12, 2020
Full time
The Laboratory Animal Sciences Program (LASP) provides exceptional quality animal care and technical support services for animal research performed at the National Cancer Institute at the Frederick National Laboratory for Cancer Research. LASP executes this mission by providing a broad spectrum of state-of-the-art technologies and services that are focused on the design, generation, characterization and application of genetically engineered and biological animal models of human disease, which are aimed at the development of targeted diagnostics and therapies. LASP contributes to advancing human health, developing new treatments, and improving existing treatments for cancer and other diseases while ensuring safe and humane treatment of animals. KEY ROLES/RESPONSIBILITIES Schedules work of several animal care groups Supervises the feeding, cleaning, and general welfare of assigned animals Ensures that physical and health examinations are performed on animals on a routine...
Frederick National Laboratory for Cancer Research Frederick, MD, USA
Sep 11, 2020
Full time
The Frederick National Laboratory for Cancer Research (FNL) is sponsored by the National Cancer Institute (NCI) and operated by the prime contractor Leidos Biomedical Research, Inc. FNL is responsible for pursuing a unique mission in translational and applied biomedical research that is unsuitable for academia, the pharmaceutical industry, or other federal contractors. This open position in Pharmacodynamics is ideally suited for a person who is more interested in applied Research & Development than in pursuing basic research knowledge. The Clinical Pharmacodynamics Biomarkers Program is responsible for identification of biomarkers of response to new targeted agents entering clinical trials in the Developmental Therapeutics Program of the National Cancer Institute. The scope of work includes assay design, development, validation, fitness for purpose testing, transfer of assays to clinical laboratories, and clinical specimen analysis when required. PADIS facilitates mechanistic...
Frederick National Laboratory for Cancer Research Frederick, MD, USA
Sep 11, 2020
Full time
PROGRAM DESCRIPTION The Clinical Pharmacodynamic Program (CPP) is responsible for identification of biomarkers of response to new targeted agents entering clinical trials in the Developmental Therapeutics Program of the National Cancer Institute (NCI). The scope of work includes assay design, development, validation, fitness for purpose testing, transfer and support of assays to internal and external clinical laboratories, and clinical specimen analysis when required. The Internal Quality Control (IQC) laboratory within the CPP program is responsible for maintaining an inventory, performing quality control testing, and distributing a large number of critical reagents and control materials to support the conduct of validated clinical pharmacodynamic assays across several technology platforms within a network of internal and external laboratories. KEY ROLES/RESPONSIBILITIES Perform incoming quality control testing on critical reagents for validated clinical pharmacodynamic...
Frederick National Laboratory for Cancer Research Rockville, MD, USA
Sep 11, 2020
Full time
Join our talented team of bioinformaticians dedicated to understanding the genetics of cancer. We are seeking an enthusiastic, creative, and collaborative bioinformatics scientist to support our broad portfolio of genome-wide association studies (GWAS). The Cancer Genomics Research Laboratory (CGR) investigates the contribution of germline and somatic genetic variation to cancer susceptibility and outcomes in support of the NCI's Division of Cancer Epidemiology and Genetics (DCEG), the world's most comprehensive cancer epidemiology research group. CGR is located at the NCI-Shady Grove campus in Gaithersburg, MD and operated by Leidos Biomedical Research, Inc. We care deeply about discovering the genetic and environmental determinants of cancer, and new approaches to cancer prevention, through our contributions to the molecular, genetic, and epidemiologic research of the 70+ investigators in DCEG. Our bioinformaticians have both the passion to learn and the opportunity to apply...
Frederick National Laboratory for Cancer Research Frederick, MD, USA
Sep 11, 2020
Full time
The Frederick National Laboratory for Cancer Research (FNL) is a Federally Funded Research and Development Center sponsored by the National Cancer Institute (NCI) and operated by the prime contractor Leidos Biomedical Research, Inc. FNL is responsible for pursuing a unique mission in translational and applied biomedical research that is unsuitable for academia, the pharmaceutical industry, or other federal contractors. This open position in is ideally suited for a research associate who is interested in applied research & development. The selected candidate will join the NCI Cancer Imaging Program (CIP) support group located at the NCI-Frederick campus. This program supports the NCI CIP by providing medical imaging agents for clinical trials, new imaging agent development, radiochemistry operations, and regulatory affairs support. Activities include procurement of investigational and production of experimental PET imaging agents for clinical and pre-clinical studies,...
Frederick National Laboratory for Cancer Research Frederick, MD, USA
Sep 10, 2020
Full time
The Biopharmaceutical Development Program (BDP) of Leidos Biomedical Research, Inc. supports the National Cancer Institute (NCI) and other government agencies through the development of novel agents for first-in-man clinical studies. KEY ROLES/RESPONSIBILITIES Reviews batch records and test results for completeness, accuracy and conformance to specifications Reviews and releases raw materials for conformance to specifications Performs in-process audits of manufacturing, analytical, and other activities Performs area clearance activities Assists with Quality Management System process audits Assists in Supplier Evaluation including auditing of CMOs, testing facilities, and other support functions Assists in the identification, documentation, investigation and follow up of quality events (deviations, corrective and preventive actions, etc.) Assists with audits from regulatory bodies and external customers Contributes to process improvement projects Writes, and...
Frederick National Laboratory for Cancer Research Bethesda, MD, USA
Sep 09, 2020
Full time
The Advanced Biomedical Computing Center (ABCC) is a part of the Biomedical Informatics and Data Science (BIDS) Program at Leidos Biomedical Research, Inc. The ABCC provides technology development, scientific consultation, collaboration and training, and high-performance computing support to the NCI and NIH scientists and staff. KEY ROLES/RESPONSIBILITIES The Bioinformatics Analyst II is responsible for providing collaborative bioinformatics support to the investigators at the National Cancer Institute (NCI). Bioinformatic Analyst II is responsible for: The analysis and interpretation of high-throughput biomedical data generated by microarray, next-generation sequencing, proteomics and metabolomics platforms Contribute to a team effort in designing, developing and deploying robust workflows, as well as custom scripts, to support the analysis of high-throughput data Mining publicly available biological data to generate novel hypotheses or insights Presenting analysis...
Frederick National Laboratory for Cancer Research Frederick, MD, USA
Sep 09, 2020
Full time
The Enterprise IT (EIT) Directorate oversees the strategic vision and implementation plan for IT systems and solutions for the enterprise at Leidos Biomedical Research, the operational information and data systems support to Frederick National Laboratory for Cancer Research. KEY ROLES/RESPONSIBILITIES EIT is recruiting for an administrator/analyst that will configure and support ongoing operations of a LIMS (LabVantage). This LIMS Analyst will provide the necessary integration between the LIMS system used by the FNL Serology lab and the SeroNet Data Coordinating Center, and integration with the Biorepository as needed. This support will include data extraction from the LIMS, any data and/or metadata transformation needed to be compliant with the SeroNet Data Coordinating Center data formats and policies, loading of the data into the SeroNet Data Coordinating Center and quality assurance checking of the loaded data. As the deployment matures, the solution and analyst will...
Frederick National Laboratory for Cancer Research Frederick, MD, USA
Sep 08, 2020
Full time
PROGRAM DESCRIPTION The Clinical Services Program's primary mission is to perform sequential studies using samples obtained from patients with cancer, AIDS, chronic granulomatous disease or other diseases associated with immunologic dysfunction, as well as to monitor viral load in patients with HIV. The Vaccine, Immunity and Cancer Program investigates immune responses to vaccines in preclinical and clinical studies, with a focus on HPV and most recently on COVID-19. KEY ROLES/RESPONSIBILITIES The Vaccine, Immunity and Cancer Program is seeking an Administrative Director, reporting to the Scientific Director. The Administrative Director will leverage scientific knowledge with strong project management and familiarity with government contracting to manage the Task Order portfolio within the Program. The Administrative Director leads all administrative responsibilities, including task order proposal preparation, management and reporting. In this capacity, the...