Eli Lilly and Company

  • Eli Lilly and Company Global Headquarters Lilly Corporate Center Indianapolis, Indiana 46285 USA
  • https://www.lilly.com
Eli Lilly and Company San Diego, CA, USA
Dec 08, 2019
Full time
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world. #WeAreLilly Responsibilities Lilly is committed to bringing innovative medicines to the patients who need them. Our Lilly Biotech Center in San Diego plays an integral part in this endeavor. The Protein BioSciences group at the Lilly Biotechnology Center San Diego seeks a motivated scientist with experience in mass spectrometry to join a dynamic team responsible for the expression, purification, and characterization of protein therapeutics. Do you have hands-on experience with mass spectrometry and the software packages associated with this technology? The primary focus of this position will be to characterize a variety of recombinant proteins, antibodies and related molecules by mass spectrometry. You will be able to utilize characterization experiments for proteins and antibodies using UPLC, LC-MS and LC-MS/MS technologies, including intact mass analysis, peptide mapping, post-translational modification analysis, etc. You will have the opportunity to disseminate results to project teams, transition teams, and legal groups in a clear and concise manner. 53272BR Basic Qualifications Bachelors in Chemistry, Biochemistry, Biology, or a similar field with at least 2 years' experience or Masters degree in Chemistry, Biochemistry, Biology, or a similar field with applicable research experience Additional Skills/Preferences Knowledge and hands-on experience with mass spectrometers instrumentation and software packages. Strong teammate with excellent communication skills Experience with mass spectrometry of monoclonal antibodies would be a plus. Experience with Thermo, Waters, and/or Agilent mass spectrometry systems and software would be considered advantageous. Additional Information Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status
Eli Lilly and Company Indianapolis, IN, USA
Dec 08, 2019
Full time
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We are looking for people who are determined to make life better for people around the world. #WeAreLilly Responsibilities The Lilly RNA Therapeutics Team is seeking a hardworking postdoctoral scientist to join our growing, fast-paced, interdisciplinary team as we leverage novel RNA/oligonucleotide based therapeutic modalities to enhance the Lilly portfolio. A postdoctoral research position exists within the RNA Therapeutics Group for an innovative researcher in the field of chemical biology. You will be responsible for methods to assess intracellular trafficking of RNA molecules which is expected to contribute to our understanding of RNAi as a platform to treat disease. Primarily, you will develop and execute protocols for the quantitative analysis of subcellular distribution and confocal imaging of RNA molecules. The experiments will encompass a combination of conjugation chemistry, protein engineering, protein labeling, cellular imaging and RNA trafficking methods. It is anticipated that the research undertaken will yield novel methods and new information that would be suited for publication in high impact scientific journals. 53480BR Basic Qualifications Ph.D. in the area of cell/molecular biology, biochemistry and related areas Additional Skills/Preferences Prior practical experience with cell biology and cell imaging Possess a solid understanding of RNA, bioconjugation strategies, and protein engineering Demonstrated track record for publication or presentation of research results Additional Information Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status. This position is not permanent. It is for a fixed duration for up to 4 years
Eli Lilly and Company Indianapolis, IN, USA
Dec 08, 2019
Full time
Lilly is the 10th largest pharmaceutical company in the world, and has been creating medicines that help improve peoples' quality of life for more than 135 years. Across the globe, we are a leader in investing in research and development and we also invest in our employees - in competitive salaries, training and development, and health. The pharmaceutical industry is a complex, rapidly changing environment and we are looking for highly capable leaders to help us continue bringing innovation to patients. If you are interested in being considered for employment at Lilly, we encourage you to review the following opportunity Responsibilities Statistical Analysis Collaborate with other statistical colleagues and study personnel to provide input to statistical analysis plans. Assist in and/or be accountable for selecting statistical methods for data analysis, authoring the corresponding sections of the analysis plan, and conducting the actual analysis once a reporting database is created. Collaborate with data management in the planning and implementation of data quality assurance plans. Maintain proficiency with respect to SAS programming and statistical methodology and in applying new and varied methods. Effectively justify methods selected and implement previously outlined analysis plans. Conduct peer-review of work products from statistical colleagues. Effectively utilize current technologies and available tools for conducting the clinical trial analysis. Communication of Results and Inferences Collaborate with other statistical colleagues to write reports and communicate results. Responsible for assisting in the communication of study results via regulatory submissions, and manuscripts, as well as for communicating one-on-one with key customers. Assist or respond to regulatory queries working in collaboration with other statistical colleagues. Therapeutic Area and Systems Knowledge: Understand relevant disease states in order to enhance the level of customer focus and collaboration. Ensure replication of tools and systems, where applicable and stay informed of technological advances. Regulatory and Quality Compliance: Perform work in full compliance with assigned curriculum(s) and will be responsible for following applicable corporate, medical, local, and departmental policies, procedures, processes, and training. 51192BR Basic Qualifications Master's degree in Statistics or Biostatistics Additional Skills/Preferences Proficiency in statistical programming languages/software such as SAS, R, Spotfire, WinBUG, etc. Interpersonal/teamwork skills for effective interactions Technical growth and application with working knowledge of statistics and statistical software Self-management skills with a focus on results for timely and accurate completion of competing deliverables Creativity and innovation Demonstrated problem solving ability and attention to detail Data analysis, technology, and systems expertise Additional Information Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status
Eli Lilly and Company Indianapolis, IN, USA
Dec 05, 2019
Full time
Lilly is a global health care leader that unites caring with discovery to make life better for people around the world. For more than a century, we have stayed true to a core set of values-excellence, integrity, and respect for people-that guide us in all we do: discovering medicines that meet real needs, improving the understanding and management of disease, and giving back to communities. We also are committed to investing in our employees and supporting a culture of well-being -through competitive pay, comprehensive employee benefit programs, and training and development resources. We're doing extraordinary things. Join us and you could be, too! Responsibilities The Clinical Project Statistician develops or assists in the development of protocol designs, clinical plans, and data analysis plans in collaboration with physicians, veterinarians, and/or medical colleagues. The Clinical Project Statistician is responsible for working with research associates and scientists to establish a reporting database and for analyzing data for these types of studies. Key Responsibilities: The job tasks listed below outline the scope of the position. The application of these tasks may vary, based upon current business needs. Statistical Trial Design and Analysis Operate in collaboration with study personnel to provide input on study protocol, design studies and write protocols for the conduct of each study. Assist in or be accountable for selecting statistical methods for data analysis, authoring the corresponding sections of the protocol, and conducting the actual analysis once a reporting database is created. Collaborate with data management in the planning and implementation of data quality assurance plans. Maintain currency with respect to statistical methodology, to maintain proficiency in applying new and varied methods, and to be competent in justifying methods selected. Participate in peer-review work products from other statistical colleagues. Communication of Results and Inferences Collaborate with team members to write reports and communicate results. Assist with, or be responsible for, communicating study results via regulatory submissions, manuscripts, or oral presentations in group settings, as well as for communicating one-on-one with key customers and presenting at scientific meetings. Respond to regulatory queries and to interact with regulators. Therapeutic Area Knowledge Understand disease states in order to enhance the level of customer focus and collaboration and be seen as a strong scientific contributor Regulatory Compliance Perform work in full compliance with assigned curriculum(s) and will be responsible for following applicable Corporate, Medical, local, and departmental policies, procedures, processes, and training. The Project Statistician at this level provides statistical leadership in multiple dimensions including: Introduces and applies innovative methodology and tools to solve critical problems Merges scientific thinking & business knowledge to identify & impact business issues. Drives projects internally (or externally), and works effectively across functions. Uses technical expertise to influence business decisions. Identifies broad technical issues, drives assessment of options and implements robust solutions. Has broad understanding of regulatory environment; demonstrates leadership on regulatory issues 52264BR Basic Qualifications PhD in Statistics or Biostatistics Additional Skills/Preferences Interpersonal communication skills for effective customer consultation Teamwork and leadership skills Technical growth and application with working knowledge of experimental design and statistics Self-management skills with a focus on results for timely and accurate completion of competing deliverables Resource management skills Creativity and innovation Demonstrated problem solving ability and strategic thinking Business process expertise associated with critical activities (e.g. regulatory submissions) Strong written and verbal communication skills: at least one manuscript submitted to or published in a peer-reviewed journal AND at least one oral presentation at a statistical conference Proficiency in statistical software (SAS OR R) Additional Information Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status
Eli Lilly and Company Indianapolis, IN, USA
Dec 05, 2019
Full time
Lilly is a global health care leader that unites caring with discovery to make life better for people around the world. For more than a century, we have stayed true to a core set of values-excellence, integrity, and respect for people-that guide us in all we do: discovering medicines that meet real needs, improving the understanding and management of disease, and giving back to communities. We also are committed to investing in our employees and supporting a culture of well-being -through competitive pay, comprehensive employee benefit programs, and training and development resources. We're doing extraordinary things. Join us and you could be, too! Responsibilities The Clinical Project Statistician develops or assists in the development of protocol designs, clinical plans, and data analysis plans in collaboration with physicians, veterinarians, and/or medical colleagues. The Clinical Project Statistician is responsible for working with research associates and scientists to establish a reporting database and for analyzing data for these types of studies. Key Responsibilities: The job tasks listed below outline the scope of the position. The application of these tasks may vary, based upon current business needs. Statistical Trial Design and Analysis Operate in collaboration with study personnel to provide input on study protocol, design studies and write protocols for the conduct of each study. Assist in or be accountable for selecting statistical methods for data analysis, authoring the corresponding sections of the protocol, and conducting the actual analysis once a reporting database is created. Collaborate with data management in the planning and implementation of data quality assurance plans. Maintain currency with respect to statistical methodology, to maintain proficiency in applying new and varied methods, and to be competent in justifying methods selected. Participate in peer-review work products from other statistical colleagues. Communication of Results and Inferences Collaborate with team members to write reports and communicate results. Assist with, or be responsible for, communicating study results via regulatory submissions, manuscripts, or oral presentations in group settings, as well as for communicating one-on-one with key customers and presenting at scientific meetings. Respond to regulatory queries and to interact with regulators. Therapeutic Area Knowledge Understand disease states in order to enhance the level of customer focus and collaboration and be seen as a strong scientific contributor Regulatory Compliance Perform work in full compliance with assigned curriculum(s) and will be responsible for following applicable Corporate, Medical, local, and departmental policies, procedures, processes, and training. The Project Statistician at this level provides statistical leadership in multiple dimensions including: Introduces and applies innovative methodology and tools to solve critical problems Merges scientific thinking & business knowledge to identify & impact business issues. Drives projects internally (or externally), and works effectively across functions. Uses technical expertise to influence business decisions. Identifies broad technical issues, drives assessment of options and implements robust solutions. Has broad understanding of regulatory environment; demonstrates leadership on regulatory issues 52264BR Basic Qualifications PhD in Statistics or Biostatistics Additional Skills/Preferences Interpersonal communication skills for effective customer consultation Teamwork and leadership skills Technical growth and application with working knowledge of experimental design and statistics Self-management skills with a focus on results for timely and accurate completion of competing deliverables Resource management skills Creativity and innovation Demonstrated problem solving ability and strategic thinking Business process expertise associated with critical activities (e.g. regulatory submissions) Strong written and verbal communication skills: at least one manuscript submitted to or published in a peer-reviewed journal AND at least one oral presentation at a statistical conference Proficiency in statistical software (SAS OR R) Additional Information Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status
Eli Lilly and Company New York, NY, USA
Dec 03, 2019
Full time
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world. #WeAreLilly Responsibilities Lilly's Immuno-Oncology Research and Development Center of Excellence in New York City is seeking a highly motivated Scientist to contribute to the development of cancer therapeutics in the Cancer Immunobiology department. The ideal scientist is expected to have a broad knowledge of cancer immunology with prior academic and/or industry experience and publications in the field. You will be responsible for leading a group of scientists to support drug discovery and development in the area of T cell redirection within the immune oncology discovery area at the Lilly NY laboratories. Some responsibilities will be in contributing to novel redirection strategies as well as the overall Immuno-Oncology portfolio. Both target identification and target validation work will be required, including independently designing and carrying out experiments, directly overseeing Research Associates in their day-to-day work, and utilizing the broader Lilly resources in a matrixed fashion to achieve goals. Ultimately it is expected that drug candidates will be carried into clinical development. This role involves both leading aspects of laboratory experiments as well as performing laboratory experiments which are designed to understand the mechanism of action of pipeline cancer therapeutics. Examples include but are not limited to developing and performing in vitro and in vivo models and assays; mammalian cell culture (primary immune cell isolation/culture), transfections, stable clone generation; flow cytometry and immunophenotyping; cell based and immunological assays including proliferation, effector function, reporter assays, T cell activation, antigen specific T cell isolation and characterization, T cell tumor killing. You may also function as scientific team lead including leading and participating in project team meetings and providing written and verbal communication of work, presentation of data and data summaries internally and externally as needed. Do you have a broad understanding of basic immunology as well as cancer immunobiology? This includes expertise in aspects of T cell priming, expansion and suppression. Experience in the area of T cell redirection is critical. It is desired to also have expertise in mechanisms of tumor mediated immune suppression. Excellent communication skills and the ability to work well independently and in a team setting are required in this role. Collaboration and teamwork are cornerstones of our research requiring you to work both independently as part of a multi-disciplinary teams and across functional areas. 51636BR Basic Qualifications PhD in Biological Sciences (e.g. Immunology, Tumor Immunology, Cell Biology or closely related discipline). Additional Skills/Preferences Prior post-doctoral and/or industry research experience in the Immuno-Oncology setting highly preferred. Additional Information Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
Eli Lilly and Company Indianapolis, IN, USA
Dec 03, 2019
Full time
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world. Responsibilities At Lilly, we unite caring with discovery to make life better for people around the world. The Biotechnology Research/ADME group is responsible for evaluating the preclinical pharmacokinetics and disposition of therapeutic proteins/peptides and monoclonal antibodies. Due to a strategic dedication to the growth of biotechnology, we are seeking a PK/PD scientist to contribute in a team environment as we leverage diverse analytical tools to characterize factors influencing the absorption, disposition, and pharmacodynamic properties of biologic therapeutics in development as drug candidates. Do you have a passion for identifying and solving scientific issues independently and within teams? Do you have experience with PK/PD modeling of large molecules? We need your skillset on our team. You will have the opportunity to: Function as a project leader in a multidisciplinary team environment with primary responsibility for the early preclinical development of antibodies and protein molecules. Integrate pharmacokinetics and PK/PD with discovery biology to define structure activity relationships guiding protein engineering strategies and optimization of protein therapeutics. Interact across groups and teams, regulatory agencies, and functional groups within drug disposition. Responsible for the design, conduct, interpretation and reporting of study results. Written and oral communication of scientific data, both internally and in the scientific community 45805BR Basic Qualifications Ph.D. in Pharmacokinetics/Pharmacodynamics or a related discipline in Pharmaceutical Sciences Experience in PK/PD modeling preferred Additional Skills/Preferences Experience using software such as WinNonlin, NONMEM and S-Plus. Industry (pharma, biotech, CRO, etc.) experience with PK/PD modeling of monoclonal antibodies, peptides/proteins or fusion proteins. Experience with oral protein delivery strategies. Experience with immunoassay and/or LC/MS methodology. Experience with drug development and knowledge of regulatory processes. Prior experience working in an interdisciplinary team. Additional Information Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
Eli Lilly and Company Indianapolis, IN, USA
Dec 03, 2019
Full time
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world. #WeAreLilly Responsibilities Position Brand Description: The microbiologist performs accurate and timely testing of routine and some non-routine lab samples in accordance with appropriate GMP and safety guidelines. The microbiologist completes second person verification of others results. The microbiologist also participates in laboratory root cause investigations, equipment evaluations and qualifications, and some quality system improvement initiatives by executing well-defined protocols and procedures. The microbiologist shares technical information and best practice within plant sites or group. Key Objectives | Deliverables Verify (SPV) analytical data of other analysts within the lab as requested. Accurately and safely perform analytical test methods or related support activities as per procedures or protocols. Uses technical knowledge in the review and interpretation of data for conformance to procedures, standards and protocols and/or real-time recognition of aberrant data and results. Perform data entry and reviews own work for accuracy in accordance with laboratory procedures, standards and GMP requirements. May perform holistic review of data for release of data from the laboratory. Recognizes when a deviation from procedures, etc has occurred and initiates and participates in a Root Cause Investigation. Performs investigations for deviations. Troubleshoot equipment and methods as required. Assist in improvement of quality systems by creating or revising worksheets and other lab documentation systems. Identifies and communicates opportunities for improvement initiatives in daily work activities. Contribute to development of PQEs. Reviews SOPs for executable as written. Shares technical information and best practice within plant sites or group. Write protocols for non-routine testing or validation with appropriate guidance. Develops equipment qualification protocols with appropriate guidance. Perform routine equipment calibrations or maintenance through execution of well-defined protocols. Comply with and implement safety standards. Executes notification to management when required by procedures or standards. Initiate change controls and deviations. Train and mentoring others. Develop training materials. 52233BR Basic Qualifications Bachelor's Degree in Microbiology; or 1 or more years of demonstrated relevant experience in a GMP (analytical chemistry, microbiology or biology) lab. Additional Skills/Preferences Responsible for maintaining a safe work environment, working safely and accountable for supporting all HSE Corporate and Site Goals. Proficiency with computer systems including Microsoft Office products, LIMS (list other lab systems), etc. Ability to working in a lab environment including wearing appropriate PPE and other safety required equipment and considerations. Demonstrated strong math and documentation skills. Demonstrated strong oral and written communication and interpersonal interaction skills. Additional Information 8 hour days - Monday through Friday with potential for additional weekend work as required. Minimal travel required. Applicant will work in various areas within the Parenteral Plant. Some allergens are present in the parenteral plant. Mobility requirements and exposure to allergens should be considered when applying for this position Required to wear a pager/cell phone off shift and respond to operational issues. Tasks may require repetitive motion (e.g., keyboarding). Post-offer testing exam may be required. This position is not permanent. It is for a fixed duration of two years with potential to extend annually for up to 4 years. Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
Eli Lilly and Company Cambridge, MA, USA
Dec 03, 2019
Full time
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world. #WeAreLilly Responsibilities Lilly is passionate about the discovery, development and commercialization of potential new medicines that will impact and improve the lives of patients. Our RNA Therapeutics team is an innovation-focused organization striving to identify, develop and apply the most cutting-edge technologies to deliver maximum benefit to our patients. Are you looking to be part of a growing, driven team where you will help to progress new therapeutic approaches toward clinical development and commercialization? Oligonucleotide-based therapies represent a promising avenue of research toward development of new RNA-based medicines. We are excited to expand our oligonucleotide research and development efforts at our Cambridge Innovation Center. The RNA Therapeutics group at Eli Lilly and Company is seeking experienced and inspiring scientists to join our fast-paced, interdisciplinary team as we leverage innovative RNA/oligonucleotide based therapeutic modalities to enhance our portfolio. This is an exciting opportunity located in the Innovation Hub of Cambridge. We aim to establish core capabilities in this novel therapeutic area and you will contribute to and help drive the discovery and development of RNA-based clinical candidates. Key Objectives/Deliverables: Deliver state of art methodologies and capabilities in the field of RNA Therapeutics by utilizing bio-chem-informatics techniques, structure-based drug design, latest machine learning and AI algorithms Play a meaningful role in the development of RNA informatics and computational platform from discovery to development Contribute to ongoing portfolio projects within RNA therapeutics Represent RNA therapeutics as a technical/scientific lead on cross-functional research teams that include discovery, development and research IT organizations Drive the evaluation of external and internal capabilities and facilitate collaborations with external partners 53648BR Basic Qualifications PhD degree in computer and information sciences, bioinformatics, cheminformatics, computational chemistry or related fields Additional Skills/Preferences Track record of innovation in developing/delivering novel methodologies, tools and applications in the field of bio/cheminformatics, structure-based drug design and machine-learning. Expertise in analyzing relationships among sequence, structure and function Practical experience in pharmaceutical or biotech industry Demonstrated experience in processing, organizing, analyzing and visualizing complex data and information from disparate sources and ability to extract insight from data Postgraduate school experience in one or more of the following areas: bioinformatics, cheminformatics, computational chemistry and machine-learning Excellent communication skills and demonstrated efficiency in collaborating across functional boundaries Extensive experience in solving scientific problems using programming languages (C++/Python/PHP/JavaScriptt/...) Experience in RNAi discovery, especially in siRNA design Experience working with Cloud (AWS) and High-Performance Computing Additional Information Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
Eli Lilly and Company Indianapolis, IN, USA
Dec 03, 2019
Full time
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We are looking for people who are determined to make life better for people around the world. #WeAreLilly Responsibilities Do you seek an opportunity to lead highly technical drug product development projects while working closely with discovery, clinical, and other development teams? Do you have strong technical problem solving ability and an internal motivation to achieve quality results in a fast-paced environment? If so, we have a role for you! Small Molecule Design and Development (SMDD) is comprised of diverse groups that design and execute the development of all CMC aspects of small molecules and non-parenteral peptides from pre-clinical phases through commercialization for drug substances and drug products. With a goal of enabling Next Generation Research and Development, we seek to develop and explore new technical solutions across our portfolio. This position will focus on the integration of early clinical and commercialization activities including clinical study and drug product design, formulation development, and global regulatory submission support. Candidates must leverage a strong background in pharmaceutical sciences, biopharmaceutics, and clinical design to fulfill responsibilities in drug product development which include: Integrating fundamental pharmaceutical sciences knowledge (formulation, biopharmaceutics, pharmacokinetics) and patient centered aspects into the design of new dosage forms and drug delivery technologies. Incorporating knowledge of disease state, therapeutic area, and molecular properties to enable drug delivery for novel or difficult to access targets. Partnering with and influencing groups at the discovery/development/ clinical interface to solve complex technical problems and to identify and implement novel formulations and clinical study designs that maximize benefit to our patients and value to Lilly. Leveraging exceptional learning agility to apply biopharmaceutics knowledge to delivery of new therapeutic modalities such as oral peptides and oligonucleotides. Embracing diverse thoughts, backgrounds, and experiences to deliver innovative pharmaceutics solutions that will allow the company to realize its vision of Next Generation Research. Influencing and engaging the external scientific community to foster collaborations for new drug delivery initiatives and to advance Lilly's internal portfolio. 52394BR Basic Qualifications Ph.D. in pharmaceutical sciences, biopharmaceutics, PK/PD or related disciplines. Additional Skills/Preferences Deep understanding of biopharmaceutics/pharmacokinetic principles, and drug product/process design factors impacting in vivo performance of drug products. Fundamental understanding of material science and impact on drug product performance and manufacturing. Knowledgeable and experienced in clinical study design. Knowledgeable in drug delivery options/systems in particular for new therapeutic modalities (e.g. peptides and oligonucleotides). Basic understanding of regulatory aspects pertaining to development and clinical testing of drug products. Additional Information Limited travel may be required Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
Eli Lilly and Company Indianapolis, IN, USA
Dec 03, 2019
Full time
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world. #WeAreLilly Responsibilities Have you wanted to work in clinical research using your ability to analyze medical images? Do you have a desire to contribute to pharmaceutical research as a core member of an Imaging Research and Development team? Lilly is looking for a dynamic scientist to join our team. Do you have strong communication, interpersonal, teamwork, and organizational skills? Have you supported clinical trial research? You will use your image analysis skills to provide technical insight to support of the clinical therapeutic portfolio. You will be computationally adept and responsible for the design, image analysis and interpretation of medical imaging in clinical trials. You will apply experience in image analysis, processing, and modeling and work cross-functionally within Lilly as well as with external imaging collaborators. We are looking for an independent, flexible and innovative scientist to work collaboratively to advance clinical image analysis and research improving the lives of our patients. In this role your responsibilities will include: Provide strategic and technical input on the development, implementation and quantitative evaluation of imaging biomarker analysis techniques in various phases of clinical development across therapeutic areas such as Oncology, and, in particular, Immuno-Oncology. Design and implement customized multi-modal image analysis (segmentation, registration, abnormality characterization) pipelines, leveraging between novel strategies and standard methodologies. Assess CT, MRI and/or PET image analysis as diagnostic and treatment response biomarkers Implement emerging technologies including computer vision, neural networks, unsupervised/supervised learning Collaborate cross-functionally with internal research and clinical (medical, operations, statistics, regulatory) teams as well as external CROs to support the validation of imaging biomarkers and their application in therapeutic development. Evaluate emerging imaging technologies, capture and communicate scientific intelligence, identify key scientific developments and implement them in the image analysis pipelines Contribute to design, editing, writing and reviewing protocols and technical imaging documents (e.g., technical manuals, imaging review charters). Communicate, present and publish results of research projects and clinical trials as appropriate. Independently conduct all stages of the projects with minimal supervision. 52634BR Basic Qualifications PhD in Medical Imaging, Biophysics, Biocomputing or related discipline with applicable training or experience utilizing medical image analysis using CT, PET and/or MRI or Master's degree in Medical Imaging, Biophysics, Biocomputing or related discipline with minimum of 5 years of professional experience utilizing medical image analysis using CT, PET and/or MRI Additional Skills/Preferences Evidence of your direct role and contribution to the medical image analysis field. This may include publications in peer-reviewed scientific journals, presentations at imaging-related conferences and/or developed software codes. Participation in oncology clinical trials and implementation of CT, MRI, and/or PET/CT treatment monitoring image analysis for immuno-oncology and other therapies. Knowledge of CT, PET and MRI procedures and acquisition protocols Implementation of emerging technologies including machine learning and artificial intelligence to the advanced tumor imaging analysis. Experience working with programing languages (MATLAB, R, etc.), image processing instruments (PMOD, etc.), and deep learning tools Statistical analysis of imaging data and experience in using statistical software tools Additional Information Ability to travel 5-10 % Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status
Eli Lilly and Company Indianapolis, IN, USA
Dec 03, 2019
Full time
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We are looking for people who are determined to make life better for people around the world. #WeAreLilly Responsibilities The Lilly RNA Therapeutics Team is seeking a hardworking postdoctoral scientist to join our growing, fast-paced, interdisciplinary team as we leverage novel RNA/oligonucleotide based therapeutic modalities to enhance the Lilly portfolio. A postdoctoral research position exists within the RNA Therapeutics Group for an innovative researcher in the field of chemical biology. You will be responsible for methods to assess intracellular trafficking of RNA molecules which is expected to contribute to our understanding of RNAi as a platform to treat disease. Primarily, you will develop and execute protocols for the quantitative analysis of subcellular distribution and confocal imaging of RNA molecules. The experiments will encompass a combination of conjugation chemistry, protein engineering, protein labeling, cellular imaging and RNA trafficking methods. It is anticipated that the research undertaken will yield novel methods and new information that would be suited for publication in high impact scientific journals. 53480BR Basic Qualifications Ph.D. in the area of cell/molecular biology, biochemistry and related areas Additional Skills/Preferences Prior practical experience with cell biology and cell imaging Possess a solid understanding of RNA, bioconjugation strategies, and protein engineering Demonstrated track record for publication or presentation of research results Additional Information Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status. This position is not permanent. It is for a fixed duration for up to 4 years
Eli Lilly and Company Cambridge, MA, USA
Dec 03, 2019
Full time
For more than 130 years, Lilly has been dedicated to meeting the health care needs of people in the United States and around the world. We address these needs primarily by developing innovative medicines-investing a higher percentage of our sales in research and development than any other major pharmaceutical company. Due to a strategic commitment to the growth of biotherapeutics within the Lilly portfolio, multiple opportunities are currently available within the Bioproduct Research and Development (BRD) and Drug Delivery and Device Research and Development (DDRD) organizations. This group is a multidisciplinary organization, focused on the development and commercialization of parenteral formulations of small molecules and large molecules such as monoclonal antibodies, insulin formulations, novel therapeutic proteins and peptides. The organization also has a unique focus on patient centered drug product and delivery system solutions utilizing both internal and external technologies. As part of this effort, Lilly has recently increased investment in Cambridge, MA to build a site dedicated to bringing in innovative solutions to drug product development and delivery challenges. As part of the investment, a Pharmaceutical Sciences and Device innovation lab has being built and co-located within the Innovation Center that consists of teams working on Formulation, Drug Delivery and Device technologies, with the goal of fostering integrated innovation among the groups. We are seeking highly motivated professionals with a start-up mentality to join our new Innovation Center in Cambridge, Massachusetts, to explore, develop and prototype new and emerging formulation and drug delivery technologies. If you have an interest in exploring new frontiers into formulation and drug delivery strategies, and use interdisciplinary problem solving methods to create breakthrough solutions for patients, you should consider joining our diverse team. At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world. #WeAreLilly Responsibilities The scientist will be responsible for evaluating new formulation and device strategies for optimizing subcutaneous drug delivery. The candidate will be conducting studies to build in-vivo and biological understanding needed to optimize the development of protein and peptide drug formulations and delivery systems. The candidate will apply expertise in various aspects of drug delivery to understand the impact of protein, formulation and device system properties on drug absorption to enable development of innovative drug products. The responsibilities for this role will include: Develop imaging techniques that can help the understanding of subcutaneous behavior of biologics in subcutaneous space. Develop and execute experiments to understand the behavior of proteins when delivered in the subcutaneous space. Work effectively in pharmaceutical sciences and device engineering teams to innovate and evaluate new drug delivery and device technologies for delivery of parenteral products Work in teams focusing on research on understanding of formulation impact on immunogenicity and pharmacokinetics, high concentration/ high volume formulations, preservative compatibility with bioproducts etc. Innovate or Assess cutting edge formulation methodologies for complex or unstable bioproducts (peptides, proteins, RNA, fusion proteins and drug conjugates) Keep abreast of relevant new technologies / capabilities and regulatory initiatives / requirements. Authoring of technical reports , research grants, journal publications and regulatory documents 53528BR Basic Qualifications PhD in Biomedical Engineering, Biology or Biochemistry Additional Skills/Preferences Experience/ knowledge of drug delivery, lipid nanoparticles, RNA and device technologies Basic understanding of Insulins, peptides, proteins, degradation pathways, and general approaches for stabilization Able to independently contribute from the bench (design and execute studies to develop a formulation) Experience/ knowledge of parenteral formulations development for preclinical, clinical and commercial use (including lyophilized and solutions formulations). In depth understanding of protein chemistry, structure and conformation, as relates to chemical and physical stability of small and large molecules. Demonstrated technical / scientific leadership skills; applied to problem-solving Good oral and written communication skills Must be able to work productively in an interdisciplinary team environment Additional Information This position is not permanent. It is for a fixed duration of two years with potential to extend annually for up to 4 years. Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
Eli Lilly and Company San Francisco, CA, USA
Nov 29, 2019
Full time
 Partner with health care professionals and those involved with patient care as a product expert to tailor solutions for patient therapy Work in your own territory and also partner with team members and alliance partners for success in the territory Sell in a changing health care environment, utilizing critical thinking and a strategic mindset to understand the environment (payer, health systems, business) and gain access to the customers to make an impact on patients' lives Achieve sales growth in territory and deliver on strong sales results Entrepreneurial mindset to analyze, develop and grow territory business Operate with high integrity and comply with Lilly policies and procedures 52470BR  Bachelors degree as well as Professional certification or license required to perform this position (if required by a specific state) Valid driver's license and acceptable driving record Qualified candidates must be legally authorized to be employed in the United States. Lilly does not anticipate providing sponsorship for employment visa status (e.g., H-1B or TN status) for this employment position
Eli Lilly and Company Manhattan, New York, NY, USA
Nov 28, 2019
Full time
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world. #WeAreLilly Responsibilities Lilly's Immuno-Oncology Research and Development Center of Excellence in New York City is seeking a highly motivated Scientist to contribute to the development of cancer therapeutics in the Cancer Immunobiology department. The ideal scientist is expected to have a broad knowledge of cancer immunology with prior academic and/or industry experience and publications in the field. You will be responsible for leading a group of scientists to support drug discovery and development in the area of T cell redirection within the immune oncology discovery area at the Lilly NY laboratories. Some responsibilities will be in contributing to novel redirection strategies as well as the overall Immuno-Oncology portfolio. Both target identification and target validation work will be required, including independently designing and carrying out experiments, directly overseeing Research Associates in their day-to-day work, and utilizing the broader Lilly resources in a matrixed fashion to achieve goals. Ultimately it is expected that drug candidates will be carried into clinical development. This role involves both leading aspects of laboratory experiments as well as performing laboratory experiments which are designed to understand the mechanism of action of pipeline cancer therapeutics. Examples include but are not limited to developing and performing in vitro and in vivo models and assays; mammalian cell culture (primary immune cell isolation/culture), transfections, stable clone generation; flow cytometry and immunophenotyping; cell based and immunological assays including proliferation, effector function, reporter assays, T cell activation, antigen specific T cell isolation and characterization, T cell tumor killing. You may also function as scientific team lead including leading and participating in project team meetings and providing written and verbal communication of work, presentation of data and data summaries internally and externally as needed. Do you have a broad understanding of basic immunology as well as cancer immunobiology? This includes expertise in aspects of T cell priming, expansion and suppression. Experience in the area of T cell redirection is critical. It is desired to also have expertise in mechanisms of tumor mediated immune suppression. Excellent communication skills and the ability to work well independently and in a team setting are required in this role. Collaboration and teamwork are cornerstones of our research requiring you to work both independently as part of a multi-disciplinary teams and across functional areas. 51636BR Basic Qualifications PhD in Biological Sciences (e.g. Immunology, Tumor Immunology, Cell Biology or closely related discipline). Additional Skills/Preferences Prior post-doctoral and/or industry research experience in the Immuno-Oncology setting highly preferred. Additional Information Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
Eli Lilly and Company Cambridge, MA, USA
Nov 27, 2019
Full time
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world. #WeAreLilly Responsibilities Lilly is passionate about the discovery, development and commercialization of potential new medicines that will impact and improve the lives of patients. Our RNA Therapeutics team is an innovation-focused organization striving to identify, develop and apply the most cutting-edge technologies to deliver maximum benefit to our patients. Are you looking to be part of a growing, driven team where you will help to progress new therapeutic approaches toward clinical development and commercialization? Oligonucleotide-based therapies represent a promising avenue of research toward development of new RNA-based medicines. We are excited to expand our oligonucleotide research and development efforts at our Cambridge Innovation Center. The RNA Therapeutics group at Eli Lilly and Company is seeking experienced and inspiring scientists to join our fast-paced, interdisciplinary team as we leverage innovative RNA/oligonucleotide based therapeutic modalities to enhance our portfolio. This is an exciting opportunity located in the Innovation Hub of Cambridge. We aim to establish core capabilities in this novel therapeutic area and you will contribute to and help drive the discovery and development of RNA-based clinical candidates. Key Objectives/Deliverables: Deliver state of art methodologies and capabilities in the field of RNA Therapeutics by utilizing bio-chem-informatics techniques, structure-based drug design, latest machine learning and AI algorithms Play a meaningful role in the development of RNA informatics and computational platform from discovery to development Contribute to ongoing portfolio projects within RNA therapeutics Represent RNA therapeutics as a technical/scientific lead on cross-functional research teams that include discovery, development and research IT organizations Drive the evaluation of external and internal capabilities and facilitate collaborations with external partners 53648BR Basic Qualifications PhD degree in computer and information sciences, bioinformatics, cheminformatics, computational chemistry or related fields Additional Skills/Preferences Track record of innovation in developing/delivering novel methodologies, tools and applications in the field of bio/cheminformatics, structure-based drug design and machine-learning. Expertise in analyzing relationships among sequence, structure and function Practical experience in pharmaceutical or biotech industry Demonstrated experience in processing, organizing, analyzing and visualizing complex data and information from disparate sources and ability to extract insight from data Postgraduate school experience in one or more of the following areas: bioinformatics, cheminformatics, computational chemistry and machine-learning Excellent communication skills and demonstrated efficiency in collaborating across functional boundaries Extensive experience in solving scientific problems using programming languages (C++/Python/PHP/JavaScriptt/...) Experience in RNAi discovery, especially in siRNA design Experience working with Cloud (AWS) and High-Performance Computing Additional Information Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
Eli Lilly and Company Indiana, USA
Nov 27, 2019
Full time
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world. #WeAreLilly Responsibilities Position Brand Description: The microbiologist performs accurate and timely testing of routine and some non-routine lab samples in accordance with appropriate GMP and safety guidelines. The microbiologist completes second person verification of others results. The microbiologist also participates in laboratory root cause investigations, equipment evaluations and qualifications, and some quality system improvement initiatives by executing well-defined protocols and procedures. The microbiologist shares technical information and best practice within plant sites or group. Key Objectives | Deliverables Verify (SPV) analytical data of other analysts within the lab as requested. Accurately and safely perform analytical test methods or related support activities as per procedures or protocols. Uses technical knowledge in the review and interpretation of data for conformance to procedures, standards and protocols and/or real-time recognition of aberrant data and results. Perform data entry and reviews own work for accuracy in accordance with laboratory procedures, standards and GMP requirements. May perform holistic review of data for release of data from the laboratory. Recognizes when a deviation from procedures, etc has occurred and initiates and participates in a Root Cause Investigation. Performs investigations for deviations. Troubleshoot equipment and methods as required. Assist in improvement of quality systems by creating or revising worksheets and other lab documentation systems. Identifies and communicates opportunities for improvement initiatives in daily work activities. Contribute to development of PQEs. Reviews SOPs for executable as written. Shares technical information and best practice within plant sites or group. Write protocols for non-routine testing or validation with appropriate guidance. Develops equipment qualification protocols with appropriate guidance. Perform routine equipment calibrations or maintenance through execution of well-defined protocols. Comply with and implement safety standards. Executes notification to management when required by procedures or standards. Initiate change controls and deviations. Train and mentoring others. Develop training materials. 52233BR Basic Qualifications Bachelor's Degree in Microbiology; or 1 or more years of demonstrated relevant experience in a GMP (analytical chemistry, microbiology or biology) lab. Additional Skills/Preferences Responsible for maintaining a safe work environment, working safely and accountable for supporting all HSE Corporate and Site Goals. Proficiency with computer systems including Microsoft Office products, LIMS (list other lab systems), etc. Ability to working in a lab environment including wearing appropriate PPE and other safety required equipment and considerations. Demonstrated strong math and documentation skills. Demonstrated strong oral and written communication and interpersonal interaction skills. Additional Information 8 hour days - Monday through Friday with potential for additional weekend work as required. Minimal travel required. Applicant will work in various areas within the Parenteral Plant. Some allergens are present in the parenteral plant. Mobility requirements and exposure to allergens should be considered when applying for this position Required to wear a pager/cell phone off shift and respond to operational issues. Tasks may require repetitive motion (e.g., keyboarding). Post-offer testing exam may be required. This position is not permanent. It is for a fixed duration of two years with potential to extend annually for up to 4 years. Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
Eli Lilly and Company Indianapolis, IN, USA
Nov 24, 2019
Full time
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world. Responsibilities At Lilly, we unite caring with discovery to make life better for people around the world. The Biotechnology Research/ADME group is responsible for evaluating the preclinical pharmacokinetics and disposition of therapeutic proteins/peptides and monoclonal antibodies. Due to a strategic dedication to the growth of biotechnology, we are seeking a PK/PD scientist to contribute in a team environment as we leverage diverse analytical tools to characterize factors influencing the absorption, disposition, and pharmacodynamic properties of biologic therapeutics in development as drug candidates. Do you have a passion for identifying and solving scientific issues independently and within teams? Do you have experience with PK/PD modeling of large molecules? We need your skillset on our team. You will have the opportunity to: Function as a project leader in a multidisciplinary team environment with primary responsibility for the early preclinical development of antibodies and protein molecules. Integrate pharmacokinetics and PK/PD with discovery biology to define structure activity relationships guiding protein engineering strategies and optimization of protein therapeutics. Interact across groups and teams, regulatory agencies, and functional groups within drug disposition. Responsible for the design, conduct, interpretation and reporting of study results. Written and oral communication of scientific data, both internally and in the scientific community 45805BR Basic Qualifications Ph.D. in Pharmacokinetics/Pharmacodynamics or a related discipline in Pharmaceutical Sciences Experience in PK/PD modeling preferred Additional Skills/Preferences Experience using software such as WinNonlin, NONMEM and S-Plus. Industry (pharma, biotech, CRO, etc.) experience with PK/PD modeling of monoclonal antibodies, peptides/proteins or fusion proteins. Experience with oral protein delivery strategies. Experience with immunoassay and/or LC/MS methodology. Experience with drug development and knowledge of regulatory processes. Prior experience working in an interdisciplinary team. Additional Information Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
Eli Lilly and Company Cambridge, MA, USA
Nov 23, 2019
Full time
For more than 130 years, Lilly has been dedicated to meeting the health care needs of people in the United States and around the world. We address these needs primarily by developing innovative medicines-investing a higher percentage of our sales in research and development than any other major pharmaceutical company. Due to a strategic commitment to the growth of biotherapeutics within the Lilly portfolio, multiple opportunities are currently available within the Bioproduct Research and Development (BRD) and Drug Delivery and Device Research and Development (DDRD) organizations. This group is a multidisciplinary organization, focused on the development and commercialization of parenteral formulations of small molecules and large molecules such as monoclonal antibodies, insulin formulations, novel therapeutic proteins and peptides. The organization also has a unique focus on patient centered drug product and delivery system solutions utilizing both internal and external technologies. As part of this effort, Lilly has recently increased investment in Cambridge, MA to build a site dedicated to bringing in innovative solutions to drug product development and delivery challenges. As part of the investment, a Pharmaceutical Sciences and Device innovation lab has being built and co-located within the Innovation Center that consists of teams working on Formulation, Drug Delivery and Device technologies, with the goal of fostering integrated innovation among the groups. We are seeking highly motivated professionals with a start-up mentality to join our new Innovation Center in Cambridge, Massachusetts, to explore, develop and prototype new and emerging formulation and drug delivery technologies. If you have an interest in exploring new frontiers into formulation and drug delivery strategies, and use interdisciplinary problem solving methods to create breakthrough solutions for patients, you should consider joining our diverse team. At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world. #WeAreLilly Responsibilities The scientist will be responsible for evaluating new formulation and device strategies for optimizing subcutaneous drug delivery. The candidate will be conducting studies to build in-vivo and biological understanding needed to optimize the development of protein and peptide drug formulations and delivery systems. The candidate will apply expertise in various aspects of drug delivery to understand the impact of protein, formulation and device system properties on drug absorption to enable development of innovative drug products. The responsibilities for this role will include: Develop imaging techniques that can help the understanding of subcutaneous behavior of biologics in subcutaneous space. Develop and execute experiments to understand the behavior of proteins when delivered in the subcutaneous space. Work effectively in pharmaceutical sciences and device engineering teams to innovate and evaluate new drug delivery and device technologies for delivery of parenteral products Work in teams focusing on research on understanding of formulation impact on immunogenicity and pharmacokinetics, high concentration/ high volume formulations, preservative compatibility with bioproducts etc. Innovate or Assess cutting edge formulation methodologies for complex or unstable bioproducts (peptides, proteins, RNA, fusion proteins and drug conjugates) Keep abreast of relevant new technologies / capabilities and regulatory initiatives / requirements. Authoring of technical reports , research grants, journal publications and regulatory documents 53528BR Basic Qualifications PhD in Biomedical Engineering, Biology or Biochemistry Additional Skills/Preferences Experience/ knowledge of drug delivery, lipid nanoparticles, RNA and device technologies Basic understanding of Insulins, peptides, proteins, degradation pathways, and general approaches for stabilization Able to independently contribute from the bench (design and execute studies to develop a formulation) Experience/ knowledge of parenteral formulations development for preclinical, clinical and commercial use (including lyophilized and solutions formulations). In depth understanding of protein chemistry, structure and conformation, as relates to chemical and physical stability of small and large molecules. Demonstrated technical / scientific leadership skills; applied to problem-solving Good oral and written communication skills Must be able to work productively in an interdisciplinary team environment Additional Information This position is not permanent. It is for a fixed duration of two years with potential to extend annually for up to 4 years. Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
Eli Lilly and Company Indianapolis, IN, USA
Nov 14, 2019
Full time
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world. #WeAreLilly Responsibilities Lilly's Small Molecule Design and Development (SMDD) is involved in key activities for the development of synthetic active pharmaceutical ingredients from pre-clinical phases through commercialization of drug substances and drug products. Our scientists develop key technical and business solutions across the portfolio using their deep technical expertise to speed up testing of the clinical hypothesis and overall drug development. SMDD tackles this diversity of responsibilities by recognizing that an even greater diversity of talents and cultures is necessary to deliver the next generation of life changing medicines to patients. SMDD is seeking outstanding engineering candidates to work within the process design and development team. The position presents an opportunity to work side by side with chemists, analytical chemists, formulation scientists and modelers to develop new technical solutions to accelerate our portfolio. The position will be based in Indianapolis where research is conducted in a new, state of the art development facility. Candidates must demonstrate a history of strong technical depth, scientific leadership and a willingness to promote a collaborative, team-based approach to problem solving. The responsibilities and opportunities for this role include: Apply chemical engineering fundamentals towards designing and optimizing drug substance/drug product processes. Design and develop novel platforms and control systems to speed up the development of synthetic molecules including small molecules, synthetic oligonucleotides and peptides. Serve as a member of integrated commercial teams responsible for the development and demonstration of new processes. Design and execute experiments in a laboratory setting and/or mathematical models to develop robust processes capable of meeting early and late phase demands. Develop the external manufacturing network, oversee activities and install key capabilities within contract manufacturing organizations (CMOs) Communicate appropriately to other functions to enable fast commercialization of drugs and to management team to enable sound business decisions. Engage in a highly collaborative work environment across and beyond SMDD and Lilly, including external academic researchers and pre-competitive collaborations. Direct and mentor less experienced scientists and engineers to deliver the portfolio and innovation projects. Publish and present original research externally, author internal technical documents and develop and document control strategies for new product registration applications (manufacturing process and development history portions). 52395BR Basic Qualifications PhD in Chemical Engineering or related discipline Additional Skills/Preferences Experience with design, development, control and optimization of unit operations Experience with modeling and simulation tools, data analytics and predictive analytics. Experience with online and offline analytical techniques and process analytical technologies (PAT). Excellent oral communication and documentation skills. Demonstrated ability to effectively collaborate with multidisciplinary teams Additional Information Lilly is an EEO/Affirmative Action Employer, and does not discriminate on the basis of race, gender, protected veteran status, disability or any other legally protected status. Travel: 0 to 10%