Vertex Pharmaceuticals

Vertex Pharmaceuticals Watertown, MA, USA
Dec 04, 2019
Full time
We are looking for a Scientist who brings enthusiasm, intellectual curiosity, scientific rigor and a desire to innovate new medicines for patients. Develop analytical methods for release and characterization of AAV gene therapy vectors. Establish molecular and cell-based assay platforms to support rapid advancement of multiple programs. Provide subject matter expertise on method transfers/qualification sat CMO. Establish sample and data management platforms and strategy. Establish product specifications and contribute to regulatory filings. Effectively collaborate with a fully integrated team to facilitate the success of projects. Additional duties and responsibilities as required. Minimum Qualifications PhD in Biochemistry, Cell & Molecular Biology, Genetics or related discipline and 1 to 3 years experience required. Master's degree and 10+ years experience or Bachelor's degree and 12+ years experience considered. Direct industry experience developing molecular and/or cell-based release and characterization assays is required. Experience working with contract research or manufacturing organizations is preferred. Experience working with viral vectors for gene therapy is a plus. Excellent communication skills with the proven ability to build open and collaborative relationships and work effectively as a member of a multidisciplinary team. Company Information Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious and life-threatening diseases. We discovered and developed the first medicines to treat the underlying cause of cystic fibrosis (CF), a rare, life-threatening genetic disease. In addition to clinical development programs in CF, Vertex has more than a dozen ongoing research programs focused on the underlying mechanisms of other serious diseases. Founded in 1989 in Cambridge, Massachusetts, our corporate headquarters is now located in Boston's Innovation District, and our international headquarters is in London, United Kingdom. We currently employ approximately 2,500 people in the United States, Europe, Canada, Australia and Latin America with nearly two-thirds of our staff dedicated to research and development. Vertex is consistently recognized as one of the industry's top places to work by Science Magazine, The Boston Globe, Boston Business Journal and the San Diego Business Journal. Our research and medicines have also received esteemed recognitions, including the Robert J. Beall Therapeutics Development Award, the French Prix Galien and the British Pharmacological Society awards. For additional information and the latest updates from the Company, please visit . Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at .
Vertex Pharmaceuticals Allston, Boston, MA 02134, USA
Dec 04, 2019
Full time
We seek a highly motivated and innovative scientist with extensive group management experience and a passion to apply biophysical techniques to drug discovery and target engagement. The ideal candidate will have a proven track record in biochemical and biophysical research including structural biology. The position will require management of biochemists and biophysicists to support recombinant protein production, protein characterization and small-molecule ligand binding for structural and mechanistic studies. Key Responsibilities Provide leadership and expertise in biophysics, protein biochemistry, and structural biology Partner with cellular biologists, computational & medicinal chemists to identify and develop high-quality lead compounds for programs Contribute to the design and execution of biophysical screening and kinetics studies to support hit identification, validation, compound progression and mechanistic studies Manage and carry out biophysical protein-ligand measurements, determine protein mechanism, and work with enzymologists for assay development Minimum Qualifications Experience in managing scientists of diverse levels of experience PhD in Biochemistry, Biophysics, Enzymology, Structural Biology or related field with 10+ years of industry experience A demonstrated track record of effectively introducing relevant new technologies to a company environment is expected. Extensive hands-on experience with biophysical methods such as SPR, MST, ITC, CD, SEC-MALS Familiarity with X-ray crystallography, cryoEM and NMR Deep understanding and extensive experience with biophysical techniques to measure and characterize protein-ligand interactions, standard molecular biology and protein biochemistry methods, protein stability, protein folding, and catalysis Skills in managing multiple projects from different therapeutic targets with clear understanding of project needs and ensuring delivery of high-quality data with clear communication of timelines Company Information Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious and life-threatening diseases. We discovered and developed the first medicines to treat the underlying cause of cystic fibrosis (CF), a rare, life-threatening genetic disease. In addition to clinical development programs in CF, Vertex has more than a dozen ongoing research programs focused on the underlying mechanisms of other serious diseases. Founded in 1989 in Cambridge, Massachusetts, our corporate headquarters is now located in Boston's Innovation District, and our international headquarters is in London, United Kingdom. We currently employ approximately 2,500 people in the United States, Europe, Canada, Australia and Latin America with nearly two-thirds of our staff dedicated to research and development. Vertex is consistently recognized as one of the industry's top places to work by Science Magazine, The Boston Globe, Boston Business Journal and the San Diego Business Journal. Our research and medicines have also received esteemed recognitions, including the Robert J. Beall Therapeutics Development Award, the French Prix Galien and the British Pharmacological Society awards. For additional information and the latest updates from the Company, please visit . Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at .
Vertex Pharmaceuticals San Diego, CA, USA
Dec 04, 2019
Full time
Vertex is seeking a proven scientific leader in Chemical Biology for our San Diego research facility. You will report to the head of chemistry and will be a member of the chemistry leadership team. This will include leading a multi-disciplinary team of scientists to design and synthesize compounds that can probe novel drug binding sites and elucidate the chemical features required for activity without the constraints of developing a drug candidate. If you have a proven track record in Chemical Biology as demonstrated by peer reviewed publications and influence in the field, we would welcome the opportunity to consider you for this newly created leadership role with us. Key Responsibilities: Integrate team activities with drug research projects and clearly articulate and communicate key questions that chemistry can help answer. Develop knowledge of and make recommendations about future applications of chemistry to tackle new types of targets, such as DNA or RNA. Stay fluent with recent developments in the Chemical Biology field including advances in tagging proteins (preferably in live cells), biochemical and/or biophysical assay development and the rapidly evolving field of protein degradation. Minimum Qualifications PhD in Chemistry or Biology and 10+ years of experience; 3-5 years' experience leading a small or mid-sized group preferably in an industrial setting Demonstrated contributions in target and drug binding site identification and validation Expertise in cell and molecular biology, biochemistry, and pharmacology and broad understanding of drug discovery Expertise in biochemical and/or biophysical tools to evaluate small molecule drug binding to target protein Experience in the application of genetic and/or computational methods to study pathways and identify targets Expertise in chemistry, especially as it relates to probe design and/ or tissue targeting Proven experience developing and mentoring group members Effective communication skills, both verbal and written Preferred Qualifications: Experience in target and drug binding site validation and/or identification Experience in planning, project leadership, laboratory and budget management Shown ability to champion and advance creative concepts Ability to manage complexity and ambiguity in a highly matrixed work environment Ability to identify and lead collaborations in chemical biology field A desire to be part of a highly innovative and dynamic company aimed at transforming the lives of people with serious diseases, their families and society Company Information Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious and life-threatening diseases. We discovered and developed the first medicines to treat the underlying cause of cystic fibrosis (CF), a rare, life-threatening genetic disease. In addition to clinical development programs in CF, Vertex has more than a dozen ongoing research programs focused on the underlying mechanisms of other serious diseases. Founded in 1989 in Cambridge, Massachusetts, our corporate headquarters is now located in Boston's Innovation District, and our international headquarters is in London, United Kingdom. We currently employ approximately 2,500 people in the United States, Europe, Canada, Australia and Latin America with nearly two-thirds of our staff dedicated to research and development. Vertex is consistently recognized as one of the industry's top places to work by Science Magazine, The Boston Globe, Boston Business Journal and the San Diego Business Journal. Our research and medicines have also received esteemed recognitions, including the Robert J. Beall Therapeutics Development Award, the French Prix Galien and the British Pharmacological Society awards. For additional information and the latest updates from the Company, please visit . Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at .