Vertex Pharmaceuticals

Vertex Pharmaceuticals Allston, Boston, MA 02134, USA
Aug 17, 2019
Full time
This role provides technical support for Release and Stability Laboratory (RSL) department supporting validation, testing and reporting of in-process, release and stability samples. Specific assigned persons are responsible to ensure activities occur in an efficient and cGMP compliant manner while fostering the Vertex vision and values. Key Responsibilities: Assist in overseeing of RSL method validations and/or method transfer activities to support project timelines. Serve as RSL representative in cross-functional, cross-departmental working teams May execute method validations and/or transfers as needed Support in the managing of RSL change controls, deviations, and investigations. Authors laboratory OOS/OOT investigations and deviations. Helps identify corrective actions to prevent reoccurrence Assist in troubleshooting of analytical methods when necessary Authors and reviews data, SOPs, analytical methods, protocols and reports Participates in compliance related teams working towards the goal of continuous improvement. #LI-BS1 Minimum Qualifications A minimum of a Bachelor Degree in science or related discipline is required. 4+ years of experience in pharmaceutical/biopharmaceutical industry with at least 1 year of method validation/transfer experience. Knowledge of US and EU cGMP regulations/guidance and some experience with regulatory agency inspections. Knowledge of analytical methodologies such as chromatography, dissolution, and Karl Fisher and applying/interpretation of GMP requirements Strong attention to detail Effective communication skills, both verbal and written. Company Information Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious and life-threatening diseases. We discovered and developed the first medicines to treat the underlying cause of cystic fibrosis (CF), a rare, life-threatening genetic disease. In addition to clinical development programs in CF, Vertex has more than a dozen ongoing research programs focused on the underlying mechanisms of other serious diseases. Founded in 1989 in Cambridge, Massachusetts, our corporate headquarters is now located in Boston's Innovation District, and our international headquarters is in London, United Kingdom. We currently employ approximately 2,500 people in the United States, Europe, Canada, Australia and Latin America with nearly two-thirds of our staff dedicated to research and development. Vertex is consistently recognized as one of the industry's top places to work by Science Magazine, The Boston Globe, Boston Business Journal and the San Diego Business Journal. Our research and medicines have also received esteemed recognitions, including the Robert J. Beall Therapeutics Development Award, the French Prix Galien and the British Pharmacological Society awards. For additional information and the latest updates from the Company, please visit . Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at .
Vertex Pharmaceuticals Allston, Boston, MA 02134, USA
Aug 17, 2019
Full time
We are seeking a creative scientist to join the Global Computational Chemistry group at Vertex and contribute to chemical reaction informatics. The successful candidate will address data analysis, visualization and decision support needs for high throughput reaction screening and synthesis planning. We are looking for a candidate with a strong background in chemistry & cheminformatics, and experience working with large reaction datasets. This position resides between medicinal and process chemistry and plays a key role in our continuing efforts to find novel, innovative treatments for serious human diseases. The ideal candidate will be responsible for the visualization of high throughput reaction screening experiments for rapid analysis and will work with chemists in the design of these experiments. In addition the candidate will work with Scientific Computing to contribute to the design of software tools to access, search, visualize and analyze datasets from such experiments. A key goal of this effort is to use reaction screening datasets to implement (or develop) methods that will enable the identification of optimal conditions/reagents for reactions and also enable prospective recommendation of reaction conditions and reagents, using modern machine learning approaches. In addition to high throughput reaction screens, the candidate will play a significant role in evaluating and applying synthesis planning tools. Given the active research on synthesis planning, the candidate will be responsible for investigating and benchmarking published approaches and commercial tools in this domain. Where relevant the candidate will perform research to develop novel methods to enhance our current capabilities. These activities will be performed in collaboration with chemists in process and medicinal chemistry and automation engineers to enable effective discovery, development and optimization of reactions across projects. Strong collaboration and communication skills are therefore essential. #LI-BS1 Minimum Qualifications PhD (or equivalent) with 2 plus years' experience in chemistry or biochemistry with a computational emphasis is required, or else a PhD or PhD equivalent in a cheminformatics or computational chemistry with a background in chemistry. Solid understanding of computer representation of reactions & molecular descriptors and a background in statistics is required. Expertise in Python, R or other programming language is essential. Experience with cheminformatics toolkits (e.g., OpenEye, RDKit) and packages (e.g., Schrodinger, MOE, KNIME) is expected. Specific expertise in predictive modeling using statistical and machine learning methods is preferred. Experience in manipulating and analyzing large internal, public and commercial datasets and with visualization of complex data types is preferred. The ideal candidate should have evidence of creative approaches to cheminformatics problems, especially in the area of chemical reactions via publications, presentations or software. Individuals with excellent communication skills and the ability to work both independently and collaboratively across our global research organization will be given preference. Additional experience in these areas would be an asset: Familiarity with one or more chemistry ELN systems. Knowledge of design of experiments (DoE) methodologies. Prior experience in synthetic chemistry. Company Information Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious and life-threatening diseases. We discovered and developed the first medicines to treat the underlying cause of cystic fibrosis (CF), a rare, life-threatening genetic disease. In addition to clinical development programs in CF, Vertex has more than a dozen ongoing research programs focused on the underlying mechanisms of other serious diseases. Founded in 1989 in Cambridge, Massachusetts, our corporate headquarters is now located in Boston's Innovation District, and our international headquarters is in London, United Kingdom. We currently employ approximately 2,500 people in the United States, Europe, Canada, Australia and Latin America with nearly two-thirds of our staff dedicated to research and development. Vertex is consistently recognized as one of the industry's top places to work by Science Magazine, The Boston Globe, Boston Business Journal and the San Diego Business Journal. Our research and medicines have also received esteemed recognitions, including the Robert J. Beall Therapeutics Development Award, the French Prix Galien and the British Pharmacological Society awards. For additional information and the latest updates from the Company, please visit . Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at .
Vertex Pharmaceuticals San Diego, CA, USA
Aug 17, 2019
Full time
Job Description We are seeking a highly motivated senior medicinal chemist to join Vertex's research site in San Diego, CA. This individual will be responsible for impacting lead optimization programs by identifying and solving tough synthetic and medicinal chemistry problems, creating project relevant hypotheses and interpretation of SAR and generating insights that influence research strategies. The ideal candidate must demonstrate a thorough knowledge of organic chemistry, be up to date with contemporary synthetic methods and show competence in the preparation of both single and focused sets of small organic molecules and development of optimized synthetic methods. This person must be a strong team player with the desire to join a highly innovative company aimed at transforming the lives of people with serious diseases, their families and society. Key Responsibilities: Designs synthetic target for lead discovery and optimization to address target potency, selectivity and pharmacokinetic properties Develops and executes clear synthetic routes using state-of-the-art synthetic methodologies Develops novel and creative solutions to overcome project and medicinal chemistry obstacles Generates effective hypotheses to pursue, followed by experimental planning and execution Makes substantive conceptual contributions to project activities and scientific strategies Imports new principles/concepts from other fields to establish new progress within the project Presents data and reports on project status at group, and departmental meetings Supports the advancement of compounds through in vitro and in vivo studies to identify development candidates Minimum Qualifications Minimum Qualifications Ph.D. (or equivalent) in Organic Chemistry or a related discipline At least 5 years of pharmaceutical or biotech experience with a demonstrated track record of contributions to drug discovery projects Detail-oriented with excellent organizational and communication skills, both verbal and written. Highly self-motivated and ability to multitask, navigate and be successful in a fast-paced, highly- matrixed team environment. Demonstrated capabilities in problem-solving and creative scientific approaches. Ability to prepare written and oral reports including publications and project plans, provide technical input, and make presentations. Company Information Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious and life-threatening diseases. We discovered and developed the first medicines to treat the underlying cause of cystic fibrosis (CF), a rare, life-threatening genetic disease. In addition to clinical development programs in CF, Vertex has more than a dozen ongoing research programs focused on the underlying mechanisms of other serious diseases. Founded in 1989 in Cambridge, Massachusetts, our corporate headquarters is now located in Boston's Innovation District, and our international headquarters is in London, United Kingdom. We currently employ approximately 2,500 people in the United States, Europe, Canada, Australia and Latin America with nearly two-thirds of our staff dedicated to research and development. Vertex is consistently recognized as one of the industry's top places to work by Science Magazine, The Boston Globe, Boston Business Journal and the San Diego Business Journal. Our research and medicines have also received esteemed recognitions, including the Robert J. Beall Therapeutics Development Award, the French Prix Galien and the British Pharmacological Society awards. For additional information and the latest updates from the Company, please visit . Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at .
Vertex Pharmaceuticals Allston, Boston, MA 02134, USA
Aug 17, 2019
Full time
Vertex is seeking a talented individual to join our Materials Assessment group in the Engineering and Material Sciences Department in Boston, MA. You will support Vertex's drug development programs by developing a more fundamental understanding of various relationships between material properties, pharmaceutical processing conditions, and final drug product performance and quality attributes. The group works to design, validate, and implement predictive models and advanced characterization techniques which connect these areas in the interest of scaling down process development and streamlining product design. These approaches are applied to Vertex's expanding drug development programs from early development up through commercialization. You will have experience as a successful technical leader in coupling experimental and computational approaches for the development of robust process models in the space of materials science, particle technology, and bulk solids processing. Examples of desired expertise include, but are not limited to: Granular physics, formulation development, discrete element modeling (DEM) with application to industrial processes, science-of-scale approaches to various granulation technologies, multi-scale characterization approaches to particles and granules, fundamental models of particle breakage, formation, feeding, and flow. #LI-BS1 Minimum Qualifications A degree in materials science, chemical engineering, mechanical engineering, or related field Ph.D. (or equivalent degree) and 7+ years of productive, relevant work or postdoctoral experience, or MS with 10+ years of relevant work experience Experience in coupling experimental design with the development of numerical / computational modeling Experience in leveraging models to streamline product development / improve manufacturing processes Validated ability to apply advanced scientific and engineering principles to describe and model the physical processes of formulation scale-up Experience applying statistical approaches in the design and analysis of experiments Proven ability to develop solutions to complex, open-ended problems with creativity and innovation Team leadership experience in a matrixed, cross-functional structure Excellent verbal and written communication skills Company Information Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious and life-threatening diseases. We discovered and developed the first medicines to treat the underlying cause of cystic fibrosis (CF), a rare, life-threatening genetic disease. In addition to clinical development programs in CF, Vertex has more than a dozen ongoing research programs focused on the underlying mechanisms of other serious diseases. Founded in 1989 in Cambridge, Massachusetts, our corporate headquarters is now located in Boston's Innovation District, and our international headquarters is in London, United Kingdom. We currently employ approximately 2,500 people in the United States, Europe, Canada, Australia and Latin America with nearly two-thirds of our staff dedicated to research and development. Vertex is consistently recognized as one of the industry's top places to work by Science Magazine, The Boston Globe, Boston Business Journal and the San Diego Business Journal. Our research and medicines have also received esteemed recognitions, including the Robert J. Beall Therapeutics Development Award, the French Prix Galien and the British Pharmacological Society awards. For additional information and the latest updates from the Company, please visit . Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at .
Vertex Pharmaceuticals Allston, Boston, MA 02134, USA
Aug 16, 2019
Full time
Job Description Vertex is seeking a talented individual to join our Formulation Development group in Boston, MA. Formulation Development group is a fast paced and high energy environment. The Associate Director in Formulation Development will lead a team of scientists dedicated to advance drug candidates from exploratory development through commercial line extension in a Quality by Design (QbD) environment using lab based and computational tools to design and select solid dosage forms and manufacturing process. The successful candidate will: Apply thoughtful ideas and scientific rigor to understanding the relational effects of small molecule formulation design and deep process understanding to achieve excellent bioperformance and to deliver robust dosage forms for clinical and commercial use. Lead a team to advance projects from exploratory development through various clinical stages to commercial validation. Challenges will include working with small molecules of poor water solubility that require extensive application of bioavailability enhancing techniques, as well as overcoming processability and scalability issues utilizing different formulations. Work in a multidisciplinary cross-functional environment, where "Fearless Pursuit of Excellence" and "We Wins" are everyday values. Proven track record of applying fundamental scientific and engineering principles to formulation design, development, and process understanding. In depth knowledge of statistical analysis. Key Responsibilities: Deliver and oversee the optimization of formulation and process understanding through rational experimental design, thoughtful execution and clear data interpretation, with a heavily emphasis on statistical analysis. Developing strategy for formulation and process development and the corresponding regulatory submissions Utilize and support the use of a mixture of computational models, small scale characterization tools, and knowledge based guidances to efficiently develop a formulation that has excellent bioperformance and can be readily manufactured at the clinical and commercial scale. Supervise a team of formulation scientists primarily dedicated to formulation design and process scale-up activities. Helps define scientific direction and champion technological innovation for the department Collaborate within CMC teams as the Formulation lead and actively contribute to deliverables and engage in team discussion on issue resolution. Serve as CMC project lead as needed. Execute and oversee technical transfers, scale up and clinical manufacture at internal and external drug-product GMP facilities. Draft and review presentations relevant to formulation development activities and present to various management levels. Be responsible for quality of direct report's scientific and quality output and maintaining a safe work environment. Mentor/develop direct reports to meet or exceed ever increasing project team deliverables and prepare to assume greater responsibilities. Author and review technical reports, regulatory filings, source documents, patents and external publications. Accountable for troubleshooting and resolving high complexity formulation challenges. #LI-BS1 Minimum Qualifications PhD degree in pharmaceutical sciences, chemistry, chemical engineering, materials science or related field with 9+ years of relevant industrial experience Demonstrated ability to apply advanced scientific principles (e.g. thermodynamics, kinetics, and materials science etc.) to formulation and process development. Demonstrated advance technological leadership. Expertise in formulation process scale-up and optimization from laboratory scale to pilot scale and readily applies engineering scale-up principles Strong background in applying statistical approaches in the design and analysis of experiments and experience with Quality by Design (QbD) Strong background in GMP manufacturing and experience with early and late stage drug product development and regulatory filings (IND/CTA, NDA/MAA) Experience in leading technical teams, project teams and direct supervisory experience Proven teamwork, leadership and collaboration skills, with a demonstrated ability to interact and influence manage all levels of business Preferred Qualifications: Expertise with alternative modalities or delivery routes (e.g. biologics, parenteral and inhalation products) is a plus Company Information Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious and life-threatening diseases. We discovered and developed the first medicines to treat the underlying cause of cystic fibrosis (CF), a rare, life-threatening genetic disease. In addition to clinical development programs in CF, Vertex has more than a dozen ongoing research programs focused on the underlying mechanisms of other serious diseases. Founded in 1989 in Cambridge, Massachusetts, our corporate headquarters is now located in Boston's Innovation District, and our international headquarters is in London, United Kingdom. We currently employ approximately 2,500 people in the United States, Europe, Canada, Australia and Latin America with nearly two-thirds of our staff dedicated to research and development. Vertex is consistently recognized as one of the industry's top places to work by Science Magazine, The Boston Globe, Boston Business Journal and the San Diego Business Journal. Our research and medicines have also received esteemed recognitions, including the Robert J. Beall Therapeutics Development Award, the French Prix Galien and the British Pharmacological Society awards. For additional information and the latest updates from the Company, please visit . Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at .
Vertex Pharmaceuticals Allston, Boston, MA 02134, USA
Aug 16, 2019
Full time
Vertex is looking for an individual to work in their High Throughput Experimentation (HTE) Lab. A successful candidate will work with colleagues to develop novel solutions to synthetic obstacles through literature work, planning, discussions and running chemistry in the HTE laboratory. Develops novel synthetic solutions to project obstacles and sets new experimental direction with the ability to work on multiple projects Makes substantive conceptual contributions to project activities and scientific strategies Provides authoritative technical recommendations to assist with solving synthetic problems Identifies broad implications of data including data capture and data mining from HTE and has interests in data visualization from an HTE perspective Works with partner lines to help achieve synthetic timelines and deliverables Has great interest in creating efficient workflows in developing new approaches to synthetic problems Has experience in setting-up and communicating results from reaction screens Has experience in using and teaching others how to use automated synthetic tools Coordinates publication, presentations and/or patenting, or is a major contributor to these processes Demonstrates initiative and ability to capitalize on scientific creativity Deep knowledge and experience in process chemistry, analytical and chemical engineering principles Ability to function effectively within a dynamic environment Consistent track record of implementing multiple successful innovation solutions A superior communicator, demonstrating the ability to write advanced technical documents and demonstrating confidence and versatility in presenting verbally to diverse audiences #LI-BS1 Minimum Qualifications MS or PhD in synthetic, organic chemistry with 4-7 years of relevant experience Experience in using the Unchained Labs equipment a plus Company Information Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious and life-threatening diseases. We discovered and developed the first medicines to treat the underlying cause of cystic fibrosis (CF), a rare, life-threatening genetic disease. In addition to clinical development programs in CF, Vertex has more than a dozen ongoing research programs focused on the underlying mechanisms of other serious diseases. Founded in 1989 in Cambridge, Massachusetts, our corporate headquarters is now located in Boston's Innovation District, and our international headquarters is in London, United Kingdom. We currently employ approximately 2,500 people in the United States, Europe, Canada, Australia and Latin America with nearly two-thirds of our staff dedicated to research and development. Vertex is consistently recognized as one of the industry's top places to work by Science Magazine, The Boston Globe, Boston Business Journal and the San Diego Business Journal. Our research and medicines have also received esteemed recognitions, including the Robert J. Beall Therapeutics Development Award, the French Prix Galien and the British Pharmacological Society awards. For additional information and the latest updates from the Company, please visit . Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at .
Vertex Pharmaceuticals Allston, Boston, MA 02134, USA
Aug 16, 2019
Full time
This role manages the data review function of Release and Stability Laboratory department supporting validation, testing and reporting of in-process, release and stability samples. Specific assigned persons are responsible for the supervision of other RSL personnel, optimizing Department resource allocation according to project/program needs to assure testing activities occur in an efficient and cGMP compliant manner while fostering the Vertex vision and values. Key Responsibilities: Coordinate laboratory testing review activities to ensure completion in a timely manner. Prioritizes resources appropriately to meet commitments on time. Ensure direct report lab personnel have adequate training, education, and experience to perform their GMP related job function effectively. Provides guidance to direct reports when issues arise Maintains and monitors related data review metrics to identify areas of focus to increase right first time Provides developmental feedback and coaching to direct reports to create a collaborative environment that attracts, develop and retains personnel. Participates in compliance related teams working towards the goal of continuous improvement. Authors and reviews data, SOPs, analytical methods, protocols and reports. May author OOS/OOT investigations and laboratory deviations. Minimum Qualifications A minimum of a Bachelor Degree in science or related discipline is required. 5+ years of experience in pharmaceutical/biopharmaceutical industry with 0-2 years of supervisory responsibility. Basic knowledge of US and EU cGMP regulations/guidance. General knowledge of analytical methodologies such as chromatography, dissolution, and Karl Fisher. Strong attention to detail. Effective communication skills, both verbal and written. Company Information Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious and life-threatening diseases. We discovered and developed the first medicines to treat the underlying cause of cystic fibrosis (CF), a rare, life-threatening genetic disease. In addition to clinical development programs in CF, Vertex has more than a dozen ongoing research programs focused on the underlying mechanisms of other serious diseases. Founded in 1989 in Cambridge, Massachusetts, our corporate headquarters is now located in Boston's Innovation District, and our international headquarters is in London, United Kingdom. We currently employ approximately 2,500 people in the United States, Europe, Canada, Australia and Latin America with nearly two-thirds of our staff dedicated to research and development. Vertex is consistently recognized as one of the industry's top places to work by Science Magazine, The Boston Globe, Boston Business Journal and the San Diego Business Journal. Our research and medicines have also received esteemed recognitions, including the Robert J. Beall Therapeutics Development Award, the French Prix Galien and the British Pharmacological Society awards. For additional information and the latest updates from the Company, please visit . Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at .
Vertex Pharmaceuticals San Diego, CA, USA
Aug 16, 2019
Full time
Company Information Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious and life-threatening diseases. We discovered and developed the first medicines to treat the underlying cause of cystic fibrosis (CF), a rare, life-threatening genetic disease. In addition to clinical development programs in CF, Vertex has more than a dozen ongoing research programs focused on the underlying mechanisms of other serious diseases. Founded in 1989 in Cambridge, Mass., Vertex today has research and development sites and offices around the world. For several consecutive years, Science magazine has named Vertex one of its Top Employers in the life sciences. For additional information and the latest updates from the Company, please visit . Vertex is seeking a proven scientific leader in Chemical Biology for our San Diego research facility. You will report to the head of chemistry and will be a member of the chemistry leadership team. This will include leading a multi-disciplinary team of scientists to design and synthesize compounds that can probe novel drug binding sites and elucidate the chemical features required for activity without the constraints of developing a drug candidate. If you have a proven track record in Chemical Biology as demonstrated by peer reviewed publications and influence in the field, we would welcome the opportunity to consider you for this newly created leadership role with us. Key Responsibilities: Integrate team activities with drug research projects and clearly articulate and communicate key questions that chemistry can help answer. Develop knowledge of and make recommendations about future applications of chemistry to tackle new types of targets, such as DNA or RNA. Stay fluent with recent developments in the Chemical Biology field including advances in tagging proteins (preferably in live cells), biochemical and/or biophysical assay development and the rapidly evolving field of protein degradation. Minimum Qualifications PhD in Chemistry or Biology and 10+ years of experience; 3-5 years' experience leading a small or mid-sized group preferably in an industrial setting Demonstrated contributions in target and drug binding site identification and validation Expertise in cell and molecular biology, biochemistry, and pharmacology and broad understanding of drug discovery Expertise in biochemical and/or biophysical tools to evaluate small molecule drug binding to target protein Experience in the application of genetic and/or computational methods to study pathways and identify targets Expertise in chemistry, especially as it relates to probe design and/ or tissue targeting Proven experience developing and mentoring group members Effective communication skills, both verbal and written Preferred Qualifications: Experience in target and drug binding site validation and/or identification Experience in planning, project leadership, laboratory and budget management Shown ability to champion and advance creative concepts Ability to manage complexity and ambiguity in a highly matrixed work environment Ability to identify and lead collaborations in chemical biology field A desire to be part of a highly innovative and dynamic company aimed at transforming the lives of people with serious diseases, their families and society Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at .
Vertex Pharmaceuticals Allston, Boston, MA 02134, USA
Aug 16, 2019
Full time
We are seeking a highly motivated scientist to act as a Clinical Biomarker Lead, working in a dynamic, cross- functional environment within the clinical development team to implement biomarker strategies for Vertex clinical assets. This position will report directly to the Head of Clinical Biomarkers. Key Responsibilities: Responsible for developing the clinical biomarker strategy for programs and implementing the biomarker plan during clinical development. Collaborate with Research and Translational Medicine on development of translational biomarker plans. Collaborate with Clinical Study Teams and colleagues in Translational Medicine and Clinical Development to ensure appropriate inclusion of Clinical Biomarkers in clinical studies, including study design. Coordinate with Clinical Pharmacology, Biostatistics and Modeling & Simulation to support quantitative pharmacological approaches during clinical development. Work with Project Management to ensure the development of Companion Diagnostics in parallel to drug development as appropriate. Serve as a key member of project teams, providing expert input to teams and guiding clinical development of novel biomarkers. Manage work with CRO and/or collaborate with colleagues from Biomarker Labs to ensure fit-for-purpose validation of clinical biomarker assays prior to implementation. Partner with colleagues across the clinical and research organizations to foster an end-to-end view of drug development, always focusing on improving patient care. Identify and lead opportunities for biomarker-focused external collaboration Minimum Qualifications Minimum Qualifications: Demonstrated experience with design, execution and analysis of clinical biomarkers of target engagement, safety, pharmacodynamics, and efficacy. Innovative and able to think creatively with a strong drive toward decision making. Effective at building alliances across functions, based on end-to-end drug development experience. Excellent interpersonal and communication skills, able to drive global collaborations across a matrixed organization. Preferred Qualifications: A PhD and/or MD with clinical biomarker development experience (at least 7+ years post-degree industry experience in the development and execution of Clinical Biomarker strategies). Experience in Neuroscience and Pain therapeutic area is desirable but not required. Company Information Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious and life-threatening diseases. We discovered and developed the first medicines to treat the underlying cause of cystic fibrosis (CF), a rare, life-threatening genetic disease. In addition to clinical development programs in CF, Vertex has more than a dozen ongoing research programs focused on the underlying mechanisms of other serious diseases. Founded in 1989 in Cambridge, Massachusetts, our corporate headquarters is now located in Boston's Innovation District, and our international headquarters is in London, United Kingdom. We currently employ approximately 2,500 people in the United States, Europe, Canada, Australia and Latin America with nearly two-thirds of our staff dedicated to research and development. Vertex is consistently recognized as one of the industry's top places to work by Science Magazine, The Boston Globe, Boston Business Journal and the San Diego Business Journal. Our research and medicines have also received esteemed recognitions, including the Robert J. Beall Therapeutics Development Award, the French Prix Galien and the British Pharmacological Society awards. For additional information and the latest updates from the Company, please visit . Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at .