Vertex Pharmaceuticals

Vertex Pharmaceuticals Boston, MA, USA
Oct 18, 2019
Full time
Job Description: Vertex Pharmaceuticals creates new possibilities in medicine to cure diseases and improve people's lives. This Senior Director, Technical Operations - Analytical opening is an exciting opportunity to join Vertex's growing Technical Operations team and play a critical role in the rapid commercialization of new life-changing products. If you are looking for an entrepreneurial, non-hierarchical, science-driven, collaborative environment where you can have a highly visible impact, then this is the perfect position for you! The Senior Director will lead all analytical activities supporting commercial products, from raw materials through drug substance, intermediates, and drug product. Responsibilities include partnering with late-stage product development teams in order to ensure the robustness of analytical methodology in a commercial setting, leading its implementation internally and at contract manufacturing facilities, and maintaining an in-house GMP lab to provide strategic support for investigations, method changes, tech transfer activities, and selected QC testing. The Senior Director is expected to lead continuous improvement opportunities throughout the method and product life-cycle and to have a robust understanding of the regulatory, quality, and business environment to in order to champion innovative strategies to support initial Market Authorizations, post-approval changes, and global expansion. The Senior Director will lead high-impact cross-functional initiatives, provide strategic input to the commercialization of new products and the direction of the Technical Operations organization, and will play a key role driving ongoing innovation in areas such as Quality-by-Design, predictive stability, continuous manufacturing and PAT. In order to assure success in this role, the candidate must be an excellent collaborator with proven experience in a cGMP pharmaceutical environment while bringing creativity and energy to all teams in order to promote positive, collaborative, and effective relationships with internal stakeholders and key external suppliers. Key Responsibilities: Represent Technical Operations in leadership forums to influence late stage product development and regulatory submission strategies, minimize commercialization risks, and foster effective post-approval and lifecycle management approaches while building strong relationships with key stakeholders. Partner with Pharmaceutical Development, Supply Chain, Quality and Regulatory to define technical transfer strategies which enable process validation and commercial manufacturing of Vertex products at new suppliers and new manufacturing sites. Design/conduct complex troubleshooting activities associated with ongoing commercial manufacturing. Participate in shaping the strategic direction of the Technical Operations department Mentor and develop staff within Technical Operations - Analytical Qualification: Minimum Qualifications: BS/MS and 16+ years or PhD with 12+ years of relevant work experience Proficient in standard analytical technology (chromatography, spectroscopy, compendial methods, etc.) Proficient in at least one other area of pharmaceutical development (e.g. solid state analysis, dissolution IVIVC, physical characterization, trace analysis, PAT/chemometrics) Experience with small molecule drug development for both drug substance and drug product (especially oral solid dosage forms) Advanced knowledge of cGMP's (e.g. Quality Control) and associated CMC regulatory considerations in a pharmaceutical setting Must be a committed team player and collaborator Preferred Qualifications: PhD in Analytical Chemistry Experience in applying QbD concepts, methodology and implementation to analytical technology and manufacturing processes Strong knowledge of DoE and statistics Experience with any or all of the following is a definite plus: cleaning validation, microbial testing, heavy metals testing, experience with regulatory submissions in Emerging Markets, post-approval change management #LI-MH
Vertex Pharmaceuticals San Diego, CA, USA
Oct 17, 2019
Full time
Vertex Pharmaceuticals Incorporated is seeking an exceptional drug discovery scientist to lead our Pharmacology department to drive the development and incorporation of modern pharmacology or new approaches. The department is comprised of approximately 15 staff who are responsible for the design, development and execution of in vitro and in vivo pharmacology assays to support progression, optimization and mechanism of action of human therapeutics. The ideal candidate must possess leadership abilities to direct and manage a team of scientists, and coordinate activities across multiple drug discovery programs. The successful candidate will serve as a member of the senior research leadership team in our San Diego site. In addition, the candidate must work well in a matrix organization, make clear decisions in a fast-paced drug discovery environment and be highly proficient in both verbal and written communication to audiences with diverse scientific, professional and drug discovery backgrounds. Minimum Qualifications: Ph.D. in Pharmacology, Molecular Biology, Cell Biology or related field with, relevant -post-doctoral employment experience 12+ years of drug discovery experience with demonstrated excellence in early stage drug discovery and development Strong strategic scientific and technical leadership in the design, execution, analysis and interpretation of a broad range of ion channel pharmacology/electrophysiology assays to drive compound progression and elucidate mechanism of action Understanding of classical pharmacological principles and drug discovery process, in order to support assessment of potency, efficacy and contribute to predictions of human efficacy Ability to critically analyze and interpret data, and effectively document and communicate results to diverse audiences Successful track record in managing functional or cross-functional research groups, including Ph.D. Scientists and Research Associates Preferred Qualifications: Experience leading groups in a pharmaceutical or biotechnology setting Assay development expertise, including biochemical and cell-based assays Evidence of development of innovative translational in vitro and/or in vivo models that predict human efficacy Company Information Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious and life-threatening diseases. We discovered and developed the first medicines to treat the underlying cause of cystic fibrosis (CF), a rare, life-threatening genetic disease. In addition to clinical development programs in CF, Vertex has more than a dozen ongoing research programs focused on the underlying mechanisms of other serious diseases. Founded in 1989 in Cambridge, Massachusetts, our corporate headquarters is now located in Boston's Innovation District, and our international headquarters is in London, United Kingdom. We currently employ approximately 2,500 people in the United States, Europe, Canada, Australia and Latin America with nearly two-thirds of our staff dedicated to research and development. Vertex is consistently recognized as one of the industry's top places to work by Science Magazine, The Boston Globe, Boston Business Journal and the San Diego Business Journal. Our research and medicines have also received esteemed recognitions, including the Robert J. Beall Therapeutics Development Award, the French Prix Galien and the British Pharmacological Society awards. For additional information and the latest updates from the Company, please visit . Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at .
Vertex Pharmaceuticals Boston, MA, USA
Oct 16, 2019
Full time
Job Description: The Senior Director, Chief of Staff is a key partner and advisor to the Chief Financial Officer on a variety of strategic, operational, and organizational matters. The role requires both strategic thinking, as well as an ability to manage complex details and drive actions across a variety of areas. The ideal candidate is a highly-motivated and highly-organized individual with exceptional communication skills and judgment. Key Responsibilities: • As a member of the CFO Leadership Team (CFOLT), work closely with the CFO and other members of the CFOLT to set strategic direction for the organization and ensure alignment with strategic objectives. • Develop and manage a process for measuring and reporting progress on high-priority initiatives and programs across the CFO's organization. Keep the CFO and other stakeholders informed on key accomplishments, issues, and next steps. • Lead and/or manage special projects and high-profile initiatives, as appropriate. • Act as a liaison between the CFO and other company senior executives, to ensure alignment and coordination on a wide variety of cross-functional initiatives. • Support the CFO in defining and developing high-impact executive communications, including presentations for Executive Committee and Board meetings, as well as CFO Town Hall meetings and other internal and external audiences. • Develop agendas and manage key meetings to ensure that important decisions and action items are fully addressed. Qualification: • Bachelor's degree required. Advanced degree preferred. • 15+ years of progressive, relevant experience with demonstrated experience as a chief of staff, or organizing and directing multiple teams and departments • Outstanding communication of information and ideas, both written and verbal, to diverse audiences. Employs active listening skills to • Strong collaboration skills, with an ability to influence multiple stakeholders. Builds mutual trust, respect and cooperation among team members. • Proven project management skills, including the ability to manage multiple tasks and priorities; adapt to new projects rapidly and effectively; Strategic thinker with a proven track record of driving for implementation • Demonstrated analytical and information technology skills • Self-motivated; Acts independently and prioritizes appropriately; Embraces unexpected changes or challenges and drives to improved solutions • Navigates organizational complexities, recommends solutions, and promotes collaboration across functions #LI-bp1
Vertex Pharmaceuticals San Diego, CA, USA
Oct 08, 2019
Full time
Vertex Pharmaceuticals Incorporated is seeking an exceptional drug discovery scientist to lead our Pharmacology department to drive the development and incorporation of modern pharmacology or new approaches. The department is comprised of approximately 15 staff who are responsible for the design, development and execution of in vitro and in vivo pharmacology assays to support progression, optimization and mechanism of action of human therapeutics. The ideal candidate must possess leadership abilities to direct and manage a team of scientists, and coordinate activities across multiple drug discovery programs. The successful candidate will serve as a member of the senior research leadership team in our San Diego site. In addition, the candidate must work well in a matrix organization, make clear decisions in a fast-paced drug discovery environment and be highly proficient in both verbal and written communication to audiences with diverse scientific, professional and drug discovery backgrounds. Minimum Qualifications: Ph.D. in Pharmacology, Molecular Biology, Cell Biology or related field with, relevant -post-doctoral employment experience 12+ years of drug discovery experience with demonstrated excellence in early stage drug discovery and development Strong strategic scientific and technical leadership in the design, execution, analysis and interpretation of a broad range of ion channel pharmacology/electrophysiology assays to drive compound progression and elucidate mechanism of action Understanding of classical pharmacological principles and drug discovery process, in order to support assessment of potency, efficacy and contribute to predictions of human efficacy Ability to critically analyze and interpret data, and effectively document and communicate results to diverse audiences Successful track record in managing functional or cross-functional research groups, including Ph.D. Scientists and Research Associates Preferred Qualifications: Experience leading groups in a pharmaceutical or biotechnology setting Assay development expertise, including biochemical and cell-based assays Evidence of development of innovative translational in vitro and/or in vivo models that predict human efficacy Company Information Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious and life-threatening diseases. We discovered and developed the first medicines to treat the underlying cause of cystic fibrosis (CF), a rare, life-threatening genetic disease. In addition to clinical development programs in CF, Vertex has more than a dozen ongoing research programs focused on the underlying mechanisms of other serious diseases. Founded in 1989 in Cambridge, Massachusetts, our corporate headquarters is now located in Boston's Innovation District, and our international headquarters is in London, United Kingdom. We currently employ approximately 2,500 people in the United States, Europe, Canada, Australia and Latin America with nearly two-thirds of our staff dedicated to research and development. Vertex is consistently recognized as one of the industry's top places to work by Science Magazine, The Boston Globe, Boston Business Journal and the San Diego Business Journal. Our research and medicines have also received esteemed recognitions, including the Robert J. Beall Therapeutics Development Award, the French Prix Galien and the British Pharmacological Society awards. For additional information and the latest updates from the Company, please visit . Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at .